Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245650653> ?p ?o ?g. }
- W4245650653 endingPage "307" @default.
- W4245650653 startingPage "301" @default.
- W4245650653 abstract "OBJECTIVE To determine whether either of the gene variants associated with age-related macular degeneration is associated with coronary artery disease (CAD). PATIENTS AND METHODS This study consisted of 493 patients who underwent clinically indicated coronary angiography between June 1, 1998, and January 1, 1999. The Y402H variant of the complement factor H (CFH) gene and the A69S variant of the LOC387715 gene locus were examined by restriction fragment length polymorphism. Multiple logistic regression models were used to assess the association of CFH and LOC gene variants with CAD. Covariates with well-established associations with CAD were also evaluated. RESULTS Seventy patients (14%) were homozygous for the histidine variant (HH) of CFH, 237 (48%) were heterozygous for the histidine variant (HY), and 186 (38%) were homozygous for the tyrosine variant (YY). Three hundred eight patients (62%) were homozygous for the alanine allele of LOC387715, 170 (34%) were heterozygous for Ala and Ser alleles, and 15 (3%) were homozygous for the serine variant. The overall association of the CFH genotype with CAD was not statistically significant (P=.08). However, some evidence (P=.046) suggested that CAD was increased for the HH genotype compared to the homozygous wild-type YY genotype (odds ratio, 1.95; 95% confidence interval, 1.01-3.76). Male sex, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and age were other variables that demonstrated significant associations with CAD. The overall effect of the LOC genotype was not statistically significant (P=.06). Heterozygosity for the serine variant was (P=.02) associated with the absence of CAD vs the AS genotype (odds ratio, 0.59; confidence interval, 0.38-0.91; P=.02). CONCLUSION The CFH genotype may have an independent association with CAD, although our evidence did not show statistical significance. Controlling for known risk factors, the age-related macular degeneration-associated HH variant appears to be associated with CAD. The LOC387715 gene may also play a role in CAD. To determine whether either of the gene variants associated with age-related macular degeneration is associated with coronary artery disease (CAD). This study consisted of 493 patients who underwent clinically indicated coronary angiography between June 1, 1998, and January 1, 1999. The Y402H variant of the complement factor H (CFH) gene and the A69S variant of the LOC387715 gene locus were examined by restriction fragment length polymorphism. Multiple logistic regression models were used to assess the association of CFH and LOC gene variants with CAD. Covariates with well-established associations with CAD were also evaluated. Seventy patients (14%) were homozygous for the histidine variant (HH) of CFH, 237 (48%) were heterozygous for the histidine variant (HY), and 186 (38%) were homozygous for the tyrosine variant (YY). Three hundred eight patients (62%) were homozygous for the alanine allele of LOC387715, 170 (34%) were heterozygous for Ala and Ser alleles, and 15 (3%) were homozygous for the serine variant. The overall association of the CFH genotype with CAD was not statistically significant (P=.08). However, some evidence (P=.046) suggested that CAD was increased for the HH genotype compared to the homozygous wild-type YY genotype (odds ratio, 1.95; 95% confidence interval, 1.01-3.76). Male sex, hypertension, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and age were other variables that demonstrated significant associations with CAD. The overall effect of the LOC genotype was not statistically significant (P=.06). Heterozygosity for the serine variant was (P=.02) associated with the absence of CAD vs the AS genotype (odds ratio, 0.59; confidence interval, 0.38-0.91; P=.02). The CFH genotype may have an independent association with CAD, although our evidence did not show statistical significance. Controlling for known risk factors, the age-related macular degeneration-associated HH variant appears to be associated with CAD. The LOC387715 gene may also play a role in CAD." @default.
- W4245650653 created "2022-05-12" @default.
- W4245650653 creator A5000992961 @default.
- W4245650653 creator A5036756435 @default.
- W4245650653 creator A5037829121 @default.
- W4245650653 creator A5041934934 @default.
- W4245650653 creator A5070584585 @default.
- W4245650653 creator A5078207171 @default.
- W4245650653 creator A5082704917 @default.
- W4245650653 creator A5084645609 @default.
- W4245650653 date "2007-03-01" @default.
- W4245650653 modified "2023-10-16" @default.
- W4245650653 title "Relationship Between Age-Related Macular Degeneration-Associated Variants of Complement Factor H and LOC387715 With Coronary Artery Disease" @default.
- W4245650653 cites W1548644132 @default.
- W4245650653 cites W1878302554 @default.
- W4245650653 cites W1966650018 @default.
- W4245650653 cites W1986337010 @default.
- W4245650653 cites W1996821302 @default.
- W4245650653 cites W1997085083 @default.
- W4245650653 cites W2016584341 @default.
- W4245650653 cites W2029034772 @default.
- W4245650653 cites W2044744070 @default.
- W4245650653 cites W2049564446 @default.
- W4245650653 cites W2057280144 @default.
- W4245650653 cites W2066326071 @default.
- W4245650653 cites W2068664566 @default.
- W4245650653 cites W2069110097 @default.
- W4245650653 cites W2082887801 @default.
- W4245650653 cites W2089946654 @default.
- W4245650653 cites W2096773438 @default.
- W4245650653 cites W2102899779 @default.
- W4245650653 cites W2104421727 @default.
- W4245650653 cites W2107143742 @default.
- W4245650653 cites W2113784410 @default.
- W4245650653 cites W2117386992 @default.
- W4245650653 cites W2125191076 @default.
- W4245650653 cites W2125236492 @default.
- W4245650653 cites W2128624830 @default.
- W4245650653 cites W2130541883 @default.
- W4245650653 cites W2131861979 @default.
- W4245650653 cites W2140653050 @default.
- W4245650653 cites W2316243284 @default.
- W4245650653 cites W3145351529 @default.
- W4245650653 cites W3185739311 @default.
- W4245650653 cites W4238550599 @default.
- W4245650653 cites W98481374 @default.
- W4245650653 doi "https://doi.org/10.1016/s0025-6196(11)61026-4" @default.
- W4245650653 hasPublicationYear "2007" @default.
- W4245650653 type Work @default.
- W4245650653 citedByCount "9" @default.
- W4245650653 countsByYear W42456506532012 @default.
- W4245650653 countsByYear W42456506532015 @default.
- W4245650653 countsByYear W42456506532017 @default.
- W4245650653 countsByYear W42456506532018 @default.
- W4245650653 countsByYear W42456506532021 @default.
- W4245650653 crossrefType "journal-article" @default.
- W4245650653 hasAuthorship W4245650653A5000992961 @default.
- W4245650653 hasAuthorship W4245650653A5036756435 @default.
- W4245650653 hasAuthorship W4245650653A5037829121 @default.
- W4245650653 hasAuthorship W4245650653A5041934934 @default.
- W4245650653 hasAuthorship W4245650653A5070584585 @default.
- W4245650653 hasAuthorship W4245650653A5078207171 @default.
- W4245650653 hasAuthorship W4245650653A5082704917 @default.
- W4245650653 hasAuthorship W4245650653A5084645609 @default.
- W4245650653 hasConcept C104317684 @default.
- W4245650653 hasConcept C111684460 @default.
- W4245650653 hasConcept C126322002 @default.
- W4245650653 hasConcept C135763542 @default.
- W4245650653 hasConcept C14356644 @default.
- W4245650653 hasConcept C156957248 @default.
- W4245650653 hasConcept C159654299 @default.
- W4245650653 hasConcept C180754005 @default.
- W4245650653 hasConcept C203014093 @default.
- W4245650653 hasConcept C2778213512 @default.
- W4245650653 hasConcept C44249647 @default.
- W4245650653 hasConcept C54355233 @default.
- W4245650653 hasConcept C71924100 @default.
- W4245650653 hasConcept C84597430 @default.
- W4245650653 hasConcept C86803240 @default.
- W4245650653 hasConcept C90924648 @default.
- W4245650653 hasConceptScore W4245650653C104317684 @default.
- W4245650653 hasConceptScore W4245650653C111684460 @default.
- W4245650653 hasConceptScore W4245650653C126322002 @default.
- W4245650653 hasConceptScore W4245650653C135763542 @default.
- W4245650653 hasConceptScore W4245650653C14356644 @default.
- W4245650653 hasConceptScore W4245650653C156957248 @default.
- W4245650653 hasConceptScore W4245650653C159654299 @default.
- W4245650653 hasConceptScore W4245650653C180754005 @default.
- W4245650653 hasConceptScore W4245650653C203014093 @default.
- W4245650653 hasConceptScore W4245650653C2778213512 @default.
- W4245650653 hasConceptScore W4245650653C44249647 @default.
- W4245650653 hasConceptScore W4245650653C54355233 @default.
- W4245650653 hasConceptScore W4245650653C71924100 @default.
- W4245650653 hasConceptScore W4245650653C84597430 @default.
- W4245650653 hasConceptScore W4245650653C86803240 @default.
- W4245650653 hasConceptScore W4245650653C90924648 @default.
- W4245650653 hasIssue "3" @default.
- W4245650653 hasLocation W42456506531 @default.