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- W4245655785 abstract "One of the most striking features of autism spectrum conditions (ASC) is that they occur significantly more often in males than in females. Despite this dramatic difference in prevalence, research on potential causes of the biased sex ratio has, until quite recently, been limited. The androgen-exposure model and the X and Y chromosome models offer interesting potential explanations for the biased sex ratio in ASC and require further research attention. While often conceived as competing theories, they may, in fact, be related as there are genes on the X chromosome which are responsive to testosterone and could modulate the production or sensitivity of an individual to testosterone. Given the possibility that ASC are highly polygenic and/or heterogeneous, it is also possible that multiple independent factors contribute to the biased sex ratio. Ultimately, a better understanding of the mechanisms underlying sex differences in the vulnerability to ASC could significantly improve diagnosis, guide research efforts into environmental risk factors, and generate novel, possibly sex-specific, therapeutic possibilities for individuals with ASC." @default.
- W4245655785 created "2022-05-12" @default.
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- W4245655785 date "2012-01-01" @default.
- W4245655785 modified "2023-10-16" @default.
- W4245655785 title "Autism" @default.
- W4245655785 doi "https://doi.org/10.1159/000336349" @default.
- W4245655785 hasPublicationYear "2012" @default.
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