Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245694828> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4245694828 abstract "The selective and efficient capture of phosphopeptides is critical for comprehensive and in-depth phosphoproteome analysis. However, this remains a significant challenge due to the inherently low abundance of these species in complex bio-samples. In this paper, we report a switchable two-dimensional (2D) supramolecular polymer that can serve as an ideal platform for the enrichment of phosphopeptides. A positively charged metallacycle incorporated into the polymer endows the material with a high affinity for phosphopeptides. Importantly, the stimuli-responsive nature of the polymer facilitates switchable binding affinity of phosphopeptides, resulting in its excellent performance in phosphopeptide enrichment and separation from model proteins. The polymer has a high enrichment capacity (165 mg/g) and detection sensitivity (2 fmol), high enrichment recovery (88%), excellent specificity, and rapid enrichment and separation properties. Additionally, we have demonstrated the capture of phosphopeptides from the tryptic digest of real bio-samples illustrating the potential of this polymeric material in phosphoproteomic studies." @default.
- W4245694828 created "2022-05-12" @default.
- W4245694828 creator A5011013044 @default.
- W4245694828 creator A5021698894 @default.
- W4245694828 creator A5037909012 @default.
- W4245694828 creator A5044756091 @default.
- W4245694828 creator A5050445168 @default.
- W4245694828 creator A5056630710 @default.
- W4245694828 creator A5073163603 @default.
- W4245694828 date "2020-09-10" @default.
- W4245694828 modified "2023-09-27" @default.
- W4245694828 title "A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment" @default.
- W4245694828 doi "https://doi.org/10.26434/chemrxiv.11292119.v2" @default.
- W4245694828 hasPublicationYear "2020" @default.
- W4245694828 type Work @default.
- W4245694828 citedByCount "0" @default.
- W4245694828 crossrefType "posted-content" @default.
- W4245694828 hasAuthorship W4245694828A5011013044 @default.
- W4245694828 hasAuthorship W4245694828A5021698894 @default.
- W4245694828 hasAuthorship W4245694828A5037909012 @default.
- W4245694828 hasAuthorship W4245694828A5044756091 @default.
- W4245694828 hasAuthorship W4245694828A5050445168 @default.
- W4245694828 hasAuthorship W4245694828A5056630710 @default.
- W4245694828 hasAuthorship W4245694828A5073163603 @default.
- W4245694828 hasBestOaLocation W42456948281 @default.
- W4245694828 hasConcept C120665830 @default.
- W4245694828 hasConcept C121332964 @default.
- W4245694828 hasConcept C135361552 @default.
- W4245694828 hasConcept C171250308 @default.
- W4245694828 hasConcept C178790620 @default.
- W4245694828 hasConcept C185592680 @default.
- W4245694828 hasConcept C192562407 @default.
- W4245694828 hasConcept C207114421 @default.
- W4245694828 hasConcept C21951064 @default.
- W4245694828 hasConcept C2779281246 @default.
- W4245694828 hasConcept C2779933727 @default.
- W4245694828 hasConcept C32909587 @default.
- W4245694828 hasConcept C43617362 @default.
- W4245694828 hasConcept C50515024 @default.
- W4245694828 hasConcept C521977710 @default.
- W4245694828 hasConcept C55493867 @default.
- W4245694828 hasConcept C93275456 @default.
- W4245694828 hasConceptScore W4245694828C120665830 @default.
- W4245694828 hasConceptScore W4245694828C121332964 @default.
- W4245694828 hasConceptScore W4245694828C135361552 @default.
- W4245694828 hasConceptScore W4245694828C171250308 @default.
- W4245694828 hasConceptScore W4245694828C178790620 @default.
- W4245694828 hasConceptScore W4245694828C185592680 @default.
- W4245694828 hasConceptScore W4245694828C192562407 @default.
- W4245694828 hasConceptScore W4245694828C207114421 @default.
- W4245694828 hasConceptScore W4245694828C21951064 @default.
- W4245694828 hasConceptScore W4245694828C2779281246 @default.
- W4245694828 hasConceptScore W4245694828C2779933727 @default.
- W4245694828 hasConceptScore W4245694828C32909587 @default.
- W4245694828 hasConceptScore W4245694828C43617362 @default.
- W4245694828 hasConceptScore W4245694828C50515024 @default.
- W4245694828 hasConceptScore W4245694828C521977710 @default.
- W4245694828 hasConceptScore W4245694828C55493867 @default.
- W4245694828 hasConceptScore W4245694828C93275456 @default.
- W4245694828 hasFunder F4320321001 @default.
- W4245694828 hasFunder F4320334704 @default.
- W4245694828 hasLocation W42456948281 @default.
- W4245694828 hasLocation W42456948282 @default.
- W4245694828 hasLocation W42456948283 @default.
- W4245694828 hasOpenAccess W4245694828 @default.
- W4245694828 hasPrimaryLocation W42456948281 @default.
- W4245694828 hasRelatedWork W2077123007 @default.
- W4245694828 hasRelatedWork W2112517787 @default.
- W4245694828 hasRelatedWork W2523690679 @default.
- W4245694828 hasRelatedWork W2800733213 @default.
- W4245694828 hasRelatedWork W2810093943 @default.
- W4245694828 hasRelatedWork W2959372526 @default.
- W4245694828 hasRelatedWork W3175338445 @default.
- W4245694828 hasRelatedWork W4233960088 @default.
- W4245694828 hasRelatedWork W4252644494 @default.
- W4245694828 hasRelatedWork W4321350521 @default.
- W4245694828 isParatext "false" @default.
- W4245694828 isRetracted "false" @default.
- W4245694828 workType "article" @default.