FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245702954> ?p ?o ?g. }

• W4245702954 endingPage "799" @default.
• W4245702954 startingPage "791" @default.
• W4245702954 abstract "Aim To compare the effect of pantoprazole and esomeprazole on intra-oesophageal pH and investigate their pharmacokinetics in patients with symptomatic gastro-oesophageal reflux disease (GORD). Methods Double-blind, randomized, two-period crossover study. Caucasian men with symptomatic GORD (n= 48) were selected on the basis of clinical records of typical GORD symptoms, confirmed by a pathological reflux time (oesophageal pH < 4 for ≥ 6% of the time). They received oral pantoprazole 40 mg once daily (od) or esomeprazole 40 mg od for seven days. Continuous 24 h oesophageal pH-metry was performed at baseline and day 7. Evaluations included: pre- and post-treatment differences in the percentage of time with pH < 4.0 and < 3.0 between baseline and day 7; area under the curve (AUC), Cmax, and T½; point estimates and 90% confidence intervals (CI) on days 1 and 7, calculated for ratios of the AUC and Cmax. Results Both drugs decreased the mean total number of reflux episodes and reduced the percentage of reflux time within 24 h to < 3%. No pathological reflux was detectable after repeated administration of either drug. The 90% CI were within the predefined range at all time points; thus, equivalence of pantoprazole and esomeprazole was concluded. For pantoprazole, Cmax and AUC were unchanged on day 7 vs day 1, confirming its high and constant bioavailability. For esomeprazole, Cmax and AUC were increased on day 7 vs day 1 by 80% and 50%, respectively, indicating low initial bioavailability. No clinically relevant side effects were seen for either drug. Conclusion Pantoprazole and esomeprazole have equivalent effect on oesophageal pH, since no pathological reflux was detected after treatment with either drug. For esomeprazole, the Cmax and AUC increased after multiple dosing; for pantoprazole the pharmacokinetics were predictable and independent of the number of administered doses." @default.
• W4245702954 created "2022-05-12" @default.
• W4245702954 creator A5009605548 @default.
• W4245702954 creator A5010147927 @default.
• W4245702954 creator A5026453326 @default.
• W4245702954 creator A5046802702 @default.
• W4245702954 creator A5057163613 @default.
• W4245702954 creator A5064313392 @default.
• W4245702954 creator A5077090708 @default.
• W4245702954 date "2003-07-01" @default.
• W4245702954 modified "2023-10-17" @default.
• W4245702954 title "Intra-oesophageal pH profiles and pharmacokinetics of pantoprazole and esomeprazole" @default.
• W4245702954 cites W1580597988 @default.
• W4245702954 cites W1966271423 @default.
• W4245702954 cites W1972776870 @default.
• W4245702954 cites W1976781864 @default.
• W4245702954 cites W1985636157 @default.
• W4245702954 cites W1998652701 @default.
• W4245702954 cites W2007711753 @default.
• W4245702954 cites W2009354071 @default.
• W4245702954 cites W2027852470 @default.
• W4245702954 cites W2039221921 @default.
• W4245702954 cites W2044475709 @default.
• W4245702954 cites W2047750046 @default.
• W4245702954 cites W2049083396 @default.
• W4245702954 cites W2054146299 @default.
• W4245702954 cites W2066910465 @default.
• W4245702954 cites W2070318597 @default.
• W4245702954 cites W2086043303 @default.
• W4245702954 cites W2087725068 @default.
• W4245702954 cites W2088317692 @default.
• W4245702954 cites W2116417173 @default.
• W4245702954 cites W2154882978 @default.
• W4245702954 cites W2615639531 @default.
• W4245702954 cites W3188786054 @default.
• W4245702954 doi "https://doi.org/10.1097/00042737-200307000-00011" @default.
• W4245702954 hasPublicationYear "2003" @default.
• W4245702954 type Work @default.
• W4245702954 citedByCount "4" @default.
• W4245702954 crossrefType "journal-article" @default.
• W4245702954 hasAuthorship W4245702954A5009605548 @default.
• W4245702954 hasAuthorship W4245702954A5010147927 @default.
• W4245702954 hasAuthorship W4245702954A5026453326 @default.
• W4245702954 hasAuthorship W4245702954A5046802702 @default.
• W4245702954 hasAuthorship W4245702954A5057163613 @default.
• W4245702954 hasAuthorship W4245702954A5064313392 @default.
• W4245702954 hasAuthorship W4245702954A5077090708 @default.
• W4245702954 hasConcept C112705442 @default.
• W4245702954 hasConcept C126322002 @default.
• W4245702954 hasConcept C142724271 @default.
• W4245702954 hasConcept C181389837 @default.
• W4245702954 hasConcept C204787440 @default.
• W4245702954 hasConcept C22979827 @default.
• W4245702954 hasConcept C27081682 @default.
• W4245702954 hasConcept C2777498785 @default.
• W4245702954 hasConcept C2778204628 @default.
• W4245702954 hasConcept C2779134260 @default.
• W4245702954 hasConcept C2781315423 @default.
• W4245702954 hasConcept C43270747 @default.
• W4245702954 hasConcept C71924100 @default.
• W4245702954 hasConcept C87813604 @default.
• W4245702954 hasConcept C90924648 @default.
• W4245702954 hasConcept C98274493 @default.
• W4245702954 hasConceptScore W4245702954C112705442 @default.
• W4245702954 hasConceptScore W4245702954C126322002 @default.
• W4245702954 hasConceptScore W4245702954C142724271 @default.
• W4245702954 hasConceptScore W4245702954C181389837 @default.
• W4245702954 hasConceptScore W4245702954C204787440 @default.
• W4245702954 hasConceptScore W4245702954C22979827 @default.
• W4245702954 hasConceptScore W4245702954C27081682 @default.
• W4245702954 hasConceptScore W4245702954C2777498785 @default.
• W4245702954 hasConceptScore W4245702954C2778204628 @default.
• W4245702954 hasConceptScore W4245702954C2779134260 @default.
• W4245702954 hasConceptScore W4245702954C2781315423 @default.
• W4245702954 hasConceptScore W4245702954C43270747 @default.
• W4245702954 hasConceptScore W4245702954C71924100 @default.
• W4245702954 hasConceptScore W4245702954C87813604 @default.
• W4245702954 hasConceptScore W4245702954C90924648 @default.
• W4245702954 hasConceptScore W4245702954C98274493 @default.
• W4245702954 hasIssue "7" @default.
• W4245702954 hasLocation W42457029541 @default.
• W4245702954 hasOpenAccess W4245702954 @default.
• W4245702954 hasPrimaryLocation W42457029541 @default.
• W4245702954 hasRelatedWork W1981005482 @default.
• W4245702954 hasRelatedWork W2179799499 @default.
• W4245702954 hasRelatedWork W2356698425 @default.
• W4245702954 hasRelatedWork W2357220270 @default.
• W4245702954 hasRelatedWork W2374069256 @default.
• W4245702954 hasRelatedWork W2379203641 @default.
• W4245702954 hasRelatedWork W2886590412 @default.
• W4245702954 hasRelatedWork W3166077597 @default.
• W4245702954 hasRelatedWork W4236136855 @default.
• W4245702954 hasRelatedWork W2094382537 @default.
• W4245702954 hasVolume "15" @default.
• W4245702954 isParatext "false" @default.
• W4245702954 isRetracted "false" @default.
• W4245702954 workType "article" @default.