Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245710094> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4245710094 endingPage "302" @default.
- W4245710094 startingPage "302" @default.
- W4245710094 abstract "Although the 2009 H1N1 pandemic influenza virus has caused about 17 000 deaths worldwide so far, the death toll in elderly people has been unexpectedly low. Now, two studies explain why elderly people have some pre-existing immunity to 2009 H1N1. The first study shows that the crystal structure of the haemagglutinin of the A/California/04/2009 H1N1 virus is very similar to that of the haemagglutinin of early 20th century human H1N1 viruses, particularly near the receptor binding domain. The second study shows that vaccination with the 1918 H1N1 pandemic influenza virus protects mice against the 2009 H1N1 virus and vice versa, and that antibodies that neutralise the pandemic strains are directed against a region of the haemagglutinin receptor binding domain that is highly conserved in the 1918 and 2009 viruses. Finally, both studies note that although this conserved region is glycosylated in seasonal H1N1 influenza strains, it is unglycosylated in both pandemic strains, which makes the region susceptible to antibody neutralisation. These results suggest ways to design vaccines to protect against similar future pandemic influenza viruses and to limit the transformation of 2009 H1N1 into seasonal influenza." @default.
- W4245710094 created "2022-05-12" @default.
- W4245710094 creator A5033003194 @default.
- W4245710094 date "2010-05-01" @default.
- W4245710094 modified "2023-09-26" @default.
- W4245710094 title "Research brief" @default.
- W4245710094 doi "https://doi.org/10.1016/s1473-3099(10)70088-8" @default.
- W4245710094 hasPublicationYear "2010" @default.
- W4245710094 type Work @default.
- W4245710094 citedByCount "0" @default.
- W4245710094 crossrefType "journal-article" @default.
- W4245710094 hasAuthorship W4245710094A5033003194 @default.
- W4245710094 hasConcept C14086860 @default.
- W4245710094 hasConcept C142724271 @default.
- W4245710094 hasConcept C159047783 @default.
- W4245710094 hasConcept C159654299 @default.
- W4245710094 hasConcept C203014093 @default.
- W4245710094 hasConcept C22070199 @default.
- W4245710094 hasConcept C2522874641 @default.
- W4245710094 hasConcept C2777546802 @default.
- W4245710094 hasConcept C2779134260 @default.
- W4245710094 hasConcept C2991839399 @default.
- W4245710094 hasConcept C3008058167 @default.
- W4245710094 hasConcept C524204448 @default.
- W4245710094 hasConcept C71924100 @default.
- W4245710094 hasConcept C7842527 @default.
- W4245710094 hasConcept C82988372 @default.
- W4245710094 hasConcept C86803240 @default.
- W4245710094 hasConcept C89623803 @default.
- W4245710094 hasConcept C99454951 @default.
- W4245710094 hasConceptScore W4245710094C14086860 @default.
- W4245710094 hasConceptScore W4245710094C142724271 @default.
- W4245710094 hasConceptScore W4245710094C159047783 @default.
- W4245710094 hasConceptScore W4245710094C159654299 @default.
- W4245710094 hasConceptScore W4245710094C203014093 @default.
- W4245710094 hasConceptScore W4245710094C22070199 @default.
- W4245710094 hasConceptScore W4245710094C2522874641 @default.
- W4245710094 hasConceptScore W4245710094C2777546802 @default.
- W4245710094 hasConceptScore W4245710094C2779134260 @default.
- W4245710094 hasConceptScore W4245710094C2991839399 @default.
- W4245710094 hasConceptScore W4245710094C3008058167 @default.
- W4245710094 hasConceptScore W4245710094C524204448 @default.
- W4245710094 hasConceptScore W4245710094C71924100 @default.
- W4245710094 hasConceptScore W4245710094C7842527 @default.
- W4245710094 hasConceptScore W4245710094C82988372 @default.
- W4245710094 hasConceptScore W4245710094C86803240 @default.
- W4245710094 hasConceptScore W4245710094C89623803 @default.
- W4245710094 hasConceptScore W4245710094C99454951 @default.
- W4245710094 hasIssue "5" @default.
- W4245710094 hasLocation W42457100941 @default.
- W4245710094 hasOpenAccess W4245710094 @default.
- W4245710094 hasPrimaryLocation W42457100941 @default.
- W4245710094 hasRelatedWork W1997397125 @default.
- W4245710094 hasRelatedWork W2038326768 @default.
- W4245710094 hasRelatedWork W2043082573 @default.
- W4245710094 hasRelatedWork W2124935992 @default.
- W4245710094 hasRelatedWork W2140347188 @default.
- W4245710094 hasRelatedWork W2286015658 @default.
- W4245710094 hasRelatedWork W2418029029 @default.
- W4245710094 hasRelatedWork W2464109635 @default.
- W4245710094 hasRelatedWork W2884424557 @default.
- W4245710094 hasRelatedWork W3119534403 @default.
- W4245710094 hasVolume "10" @default.
- W4245710094 isParatext "false" @default.
- W4245710094 isRetracted "false" @default.
- W4245710094 workType "article" @default.