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- W4245794558 abstract "Direct comparisons between atrophy and hypometabolism in Alzheimer's disease (AD) have allowed unraveling topographic discrepancies that pointed to specific pathological processes. To date, this has never been assessed in semantic dementia (SD) although atrophy and hypometabolism appear more similar than in AD as they both concern the anterior temporal lobe. Therefore, the aim of the present study was to compare atrophy versus hypometabolism discrepancies in SD to that observed in AD in order to highlight similarities and differences in the pathological processes between both diseases. Sixteen patients with SD, 24 patients with AD and 39 healthy controls matched for age, sex and years of education underwent both structural MRI and 18F-fluorodeoxyglucose PET scans. Images were spatially normalized using dartel in SPM. Age-adjusted Z-score maps were then computed for each patient and each imaging modality using the healthy controls group as a reference. Direct between-modality voxel-wise comparisons were then performed within each patient group. Between-modality analyses highlighted more atrophy than hypometabolism in the medial temporal lobe in both SD and AD (FWE p<.05). By contrast, more hypometabolism than atrophy was found in extended medial and lateral parietal regions, temporo-parietal and frontal areas in AD, and in much more restricted brain regions in SD, i.e. mainly in the prefrontal regions when using a more liberal threshold (p<.001 uncorrected)." @default.
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- W4245794558 date "2015-07-01" @default.
- W4245794558 modified "2023-09-30" @default.
- W4245794558 title "P2-137: Direct comparisons between atrophy and hypometabolism in semantic dementia and Alzheimer's disease suggest distinct neuropathological processes" @default.
- W4245794558 doi "https://doi.org/10.1016/j.jalz.2015.06.675" @default.
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