Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245853923> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4245853923 endingPage "3787" @default.
- W4245853923 startingPage "3782" @default.
- W4245853923 abstract "The viral macrophage inflammatory protein-II (vMIP-II) encoded by Kaposi's sarcoma-associated herpesvirus is unique among all known chemokines in that vMIP-II shows a broad-spectrum interaction with both CC and CXC chemokine receptors including CCR5 and CXCR4, two principal coreceptors for the cell entry of human immunodeficiency virus type 1 (HIV-1). To elucidate the mechanism of the promiscuous receptor interaction of vMIP-II, synthetic peptides derived from the N-terminus of vMIP-II were studied. In contrast to the full-length protein that recognizes both CXCR4 and CCR5, a peptide corresponding to residues 1-21 of vMIP-II (LGASWHRPDKCCLGYQKRPLP) was shown to strongly bind CXCR4, but not CCR5. The IC(50) of this peptide in competing with CXCR4 binding of (125)I-SDF-1alpha is 190 nM as compared to the IC(50) of 14.8 nM of native vMIP-II in the same assay. The peptide selectively prevented CXCR4 signal transduction and coreceptor function in mediating the entry of T- and dual-tropic HIV-1 isolates, but not those of CCR5. Further analysis of truncated peptide analogues revealed the importance of the first five residues for the activity with CXCR4. These results suggest that the N-terminus of vMIP-II is essential for its function via CXCR4. In addition, they reveal a possible mechanism for the distinctive interactions of vMIP-II with different chemokine receptors, a notion that may be further exploited to dissect the structural basis of its promiscuous biological function. Finally, the potent CXCR4 peptide antagonist shown here could serve as a lead for the development of new therapeutic agents for HIV infection and other immune system diseases." @default.
- W4245853923 created "2022-05-12" @default.
- W4245853923 creator A5015179463 @default.
- W4245853923 creator A5043422612 @default.
- W4245853923 creator A5048886458 @default.
- W4245853923 creator A5050300430 @default.
- W4245853923 creator A5068120414 @default.
- W4245853923 date "2000-03-07" @default.
- W4245853923 modified "2023-10-14" @default.
- W4245853923 title "A Novel Peptide Antagonist of CXCR4 Derived from the N-Terminus of Viral Chemokine vMIP-II" @default.
- W4245853923 cites W1579558830 @default.
- W4245853923 cites W1964083898 @default.
- W4245853923 cites W1973473416 @default.
- W4245853923 cites W2075416959 @default.
- W4245853923 cites W2079111885 @default.
- W4245853923 cites W2110221662 @default.
- W4245853923 cites W2113222286 @default.
- W4245853923 cites W2117394497 @default.
- W4245853923 cites W2119261083 @default.
- W4245853923 cites W2142655367 @default.
- W4245853923 cites W2149735135 @default.
- W4245853923 cites W2150898533 @default.
- W4245853923 cites W2170119258 @default.
- W4245853923 doi "https://doi.org/10.1021/bi992750v" @default.
- W4245853923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10736178" @default.
- W4245853923 hasPublicationYear "2000" @default.
- W4245853923 type Work @default.
- W4245853923 citedByCount "53" @default.
- W4245853923 countsByYear W42458539232012 @default.
- W4245853923 countsByYear W42458539232013 @default.
- W4245853923 countsByYear W42458539232014 @default.
- W4245853923 countsByYear W42458539232015 @default.
- W4245853923 countsByYear W42458539232016 @default.
- W4245853923 countsByYear W42458539232017 @default.
- W4245853923 countsByYear W42458539232018 @default.
- W4245853923 countsByYear W42458539232019 @default.
- W4245853923 countsByYear W42458539232020 @default.
- W4245853923 countsByYear W42458539232021 @default.
- W4245853923 countsByYear W42458539232022 @default.
- W4245853923 crossrefType "journal-article" @default.
- W4245853923 hasAuthorship W4245853923A5015179463 @default.
- W4245853923 hasAuthorship W4245853923A5043422612 @default.
- W4245853923 hasAuthorship W4245853923A5048886458 @default.
- W4245853923 hasAuthorship W4245853923A5050300430 @default.
- W4245853923 hasAuthorship W4245853923A5068120414 @default.
- W4245853923 hasConcept C12823836 @default.
- W4245853923 hasConcept C129470790 @default.
- W4245853923 hasConcept C13373296 @default.
- W4245853923 hasConcept C159047783 @default.
- W4245853923 hasConcept C170493617 @default.
- W4245853923 hasConcept C185592680 @default.
- W4245853923 hasConcept C2779281246 @default.
- W4245853923 hasConcept C2780492938 @default.
- W4245853923 hasConcept C45240729 @default.
- W4245853923 hasConcept C55493867 @default.
- W4245853923 hasConcept C84913492 @default.
- W4245853923 hasConcept C86803240 @default.
- W4245853923 hasConcept C95444343 @default.
- W4245853923 hasConceptScore W4245853923C12823836 @default.
- W4245853923 hasConceptScore W4245853923C129470790 @default.
- W4245853923 hasConceptScore W4245853923C13373296 @default.
- W4245853923 hasConceptScore W4245853923C159047783 @default.
- W4245853923 hasConceptScore W4245853923C170493617 @default.
- W4245853923 hasConceptScore W4245853923C185592680 @default.
- W4245853923 hasConceptScore W4245853923C2779281246 @default.
- W4245853923 hasConceptScore W4245853923C2780492938 @default.
- W4245853923 hasConceptScore W4245853923C45240729 @default.
- W4245853923 hasConceptScore W4245853923C55493867 @default.
- W4245853923 hasConceptScore W4245853923C84913492 @default.
- W4245853923 hasConceptScore W4245853923C86803240 @default.
- W4245853923 hasConceptScore W4245853923C95444343 @default.
- W4245853923 hasIssue "13" @default.
- W4245853923 hasLocation W42458539231 @default.
- W4245853923 hasLocation W42458539232 @default.
- W4245853923 hasOpenAccess W4245853923 @default.
- W4245853923 hasPrimaryLocation W42458539231 @default.
- W4245853923 hasRelatedWork W1557110392 @default.
- W4245853923 hasRelatedWork W1965485473 @default.
- W4245853923 hasRelatedWork W1969454135 @default.
- W4245853923 hasRelatedWork W1995992093 @default.
- W4245853923 hasRelatedWork W2028509107 @default.
- W4245853923 hasRelatedWork W2086049503 @default.
- W4245853923 hasRelatedWork W2386608521 @default.
- W4245853923 hasRelatedWork W2601059347 @default.
- W4245853923 hasRelatedWork W2793646998 @default.
- W4245853923 hasRelatedWork W4318777402 @default.
- W4245853923 hasVolume "39" @default.
- W4245853923 isParatext "false" @default.
- W4245853923 isRetracted "false" @default.
- W4245853923 workType "article" @default.