FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245860106> ?p ?o ?g. }

• W4245860106 endingPage "107" @default.
• W4245860106 startingPage "97" @default.
• W4245860106 abstract "Objective: We hypothesized that deficiency in 25-hydroxyvitamin D prior to hospital admission would be associated with sepsis in the critically ill. Design: Two-center observational study of patients treated in medical and surgical ICUs. Setting: Two hundred nine medical and surgical intensive care beds in two teaching hospitals in Boston, MA. Patients: Three thousand three hundred eighty-six patients, 18 years old or older, in whom 25-hydroxyvitamin D was measured prior to hospitalization between 1998 and 2011. Interventions: None Measurements and Main Results: Preadmission 25-hydroxyvitamin D was categorized as deficiency in 25-hydroxyvitamin D (≤ 15 ng/mL), insufficiency (15–30 ng/mL), and sufficiency (≥ 30 ng/mL). The primary outcome was sepsis as defined by International Classification of Diseases, 9th Edition, Clinical Modification and validated by the 2001 Society of Critical Care Medicine/European Society of Intensive Care Medicine, American College of Chest Physicians, American Thoracic Society, and Surgical Infection Society international sepsis definitions conference guidelines. Logistic regression examined the presence of sepsis 3 days prior to critical care initiation to 7 days after critical care initiation. Adjusted odds ratios were estimated by multivariable logistic regression models. Preadmission 25-hydroxyvitamin D deficiency is predictive for the risk of sepsis. In the full cohort, 25-hydroxyvitamin D deficiency is a significant predictor for the risk of International Classification of Diseases, 9th Edition, Clinical Modification–defined sepsis following multivariable adjustment, including age, gender, race, type (surgical vs medical), and Deyo-Charlson index (adjusted odds ratio, 1.51 [95% CI, 1.17–1.94]; p = 0.001) relative to patients with 25-hydroxyvitamin D sufficiency. In a subset of cohort patients enriched for those with International Classification of Diseases, 9th Edition, Clinical Modification–diagnosed sepsis (n = 444), preadmission 25-hydroxyvitamin D deficiency is a significant predictor for the risk of conference guideline-defined sepsis following multivariable adjustment, including age, gender, race, type (surgical vs medical), and Acute Physiology and Chronic Health Evaluation II (adjusted odds ratio, 2.05 [95% CI, 1.19–3.52]; p = 0.009) relative to patients with 25-hydroxyvitamin D sufficiency. Furthermore, in cohort patients with International Classification of Diseases, 9th Edition, Clinical Modification–defined sepsis (n = 568), the multivariable adjusted risk of 90-day mortality was 1.6-fold higher in those with preadmission 25-hydroxyvitamin D values in the insufficient and deficient range, compared with those with preadmission vitamin D sufficiency (adjusted odds ratio, 1.63 [95% CI, 1.11–2.39]; p = 0.01). Conclusion: 25-hydroxyvitamin D deficiency prior to hospital admission is a significant predictor of sepsis in the critically ill. Additionally, patients with sepsis who are not vitamin D sufficient have an increased risk of mortality following critical care initiation." @default.
• W4245860106 created "2022-05-12" @default.
• W4245860106 creator A5038373228 @default.
• W4245860106 creator A5043950050 @default.
• W4245860106 creator A5045639020 @default.
• W4245860106 creator A5059541450 @default.
• W4245860106 creator A5066324198 @default.
• W4245860106 creator A5080271739 @default.
• W4245860106 date "2014-01-01" @default.
• W4245860106 modified "2023-10-09" @default.
• W4245860106 title "Association of Low Serum 25-Hydroxyvitamin D Levels and Sepsis in the Critically Ill" @default.
• W4245860106 cites W1547708675 @default.
• W4245860106 cites W1553564414 @default.
• W4245860106 cites W1573445859 @default.
• W4245860106 cites W1854781184 @default.
• W4245860106 cites W1909391377 @default.
• W4245860106 cites W1927671826 @default.
• W4245860106 cites W1967256806 @default.
• W4245860106 cites W1968951988 @default.
• W4245860106 cites W1979851080 @default.
• W4245860106 cites W1983987058 @default.
• W4245860106 cites W1984308741 @default.
• W4245860106 cites W1985558958 @default.
• W4245860106 cites W1989205575 @default.
• W4245860106 cites W1992327808 @default.
• W4245860106 cites W1993263877 @default.
• W4245860106 cites W1995158135 @default.
• W4245860106 cites W2000445173 @default.
• W4245860106 cites W2012477225 @default.
• W4245860106 cites W2012765332 @default.
• W4245860106 cites W2013097711 @default.
• W4245860106 cites W2018207514 @default.
• W4245860106 cites W2018938924 @default.
• W4245860106 cites W2020011857 @default.
• W4245860106 cites W2021409342 @default.
• W4245860106 cites W2022261106 @default.
• W4245860106 cites W2023898565 @default.
• W4245860106 cites W2024196288 @default.
• W4245860106 cites W2026131789 @default.
• W4245860106 cites W2031746740 @default.
• W4245860106 cites W2035139971 @default.
• W4245860106 cites W2036017766 @default.
• W4245860106 cites W2037435068 @default.
• W4245860106 cites W2037745280 @default.
• W4245860106 cites W2038972175 @default.
• W4245860106 cites W2039369945 @default.
• W4245860106 cites W2050848061 @default.
• W4245860106 cites W2060206383 @default.
• W4245860106 cites W2061326496 @default.
• W4245860106 cites W2062361583 @default.
• W4245860106 cites W2063116767 @default.
• W4245860106 cites W2065896405 @default.
• W4245860106 cites W2067199708 @default.
• W4245860106 cites W2067742532 @default.
• W4245860106 cites W2068698172 @default.
• W4245860106 cites W2069990562 @default.
• W4245860106 cites W2070058460 @default.
• W4245860106 cites W2078591650 @default.
• W4245860106 cites W2087181300 @default.
• W4245860106 cites W2087203965 @default.
• W4245860106 cites W2102017163 @default.
• W4245860106 cites W2104234101 @default.
• W4245860106 cites W2106044877 @default.
• W4245860106 cites W2106449126 @default.
• W4245860106 cites W2110317531 @default.
• W4245860106 cites W2113537333 @default.
• W4245860106 cites W2115710851 @default.
• W4245860106 cites W2115734521 @default.
• W4245860106 cites W2118463883 @default.
• W4245860106 cites W2122007855 @default.
• W4245860106 cites W2124070987 @default.
• W4245860106 cites W2124580054 @default.
• W4245860106 cites W2131264460 @default.
• W4245860106 cites W2137854100 @default.
• W4245860106 cites W2141607669 @default.
• W4245860106 cites W2145577370 @default.
• W4245860106 cites W2146035663 @default.
• W4245860106 cites W2147100699 @default.
• W4245860106 cites W2149411758 @default.
• W4245860106 cites W2150692938 @default.
• W4245860106 cites W2152772601 @default.
• W4245860106 cites W2153059487 @default.
• W4245860106 cites W2154408193 @default.
• W4245860106 cites W2156264518 @default.
• W4245860106 cites W2157243060 @default.
• W4245860106 cites W2157326702 @default.
• W4245860106 cites W2163754966 @default.
• W4245860106 cites W2164413420 @default.
• W4245860106 cites W2170814415 @default.
• W4245860106 cites W2173560901 @default.
• W4245860106 cites W2320714558 @default.
• W4245860106 cites W2325704874 @default.
• W4245860106 cites W2415286928 @default.
• W4245860106 cites W4239292811 @default.
• W4245860106 cites W4293241248 @default.
• W4245860106 cites W4293242440 @default.
• W4245860106 cites W4362207774 @default.
• W4245860106 cites W77247516 @default.

• next