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- W4245870525 abstract "Reduced expression of the proto-oncogene c-myb appears necessary for erythroid differentiation induced by chemical agents and by the natural regulator, erythropoietin (Epo). Treatment of Epo-responsive Rauscher erythroleukemia cells with an anti-sense oligodeoxynucleotide to c-myb in the absence of other inducers downregulated myb protein markedly and caused hemoglobinization of the cells within 48 hours. Epo treatment, which downregulates c-myb in these cells, induced hemoglobinization to the same degree. Epo also induced the appearance of anion transport protein on the plasma membrane, consistent with terminal differentiation. In contrast, antisense c-myb did not induce this erythroid marker. The results are consistent with a role for myb protein in the regulation of hemoglobin synthesis." @default.
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- W4245870525 date "1991-08-15" @default.
- W4245870525 modified "2023-10-09" @default.
- W4245870525 title "Induction of hemoglobin synthesis by downregulation of MYB protein with an antisense oligodeoxynucleotide" @default.
- W4245870525 doi "https://doi.org/10.1182/blood.v78.4.991.bloodjournal784991" @default.
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