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- W4245871013 abstract "Abstract Mass spectrometry has become an essential analytical tool at every stage of the drug discovery and development process. Although mass spectrometry is essential for the characterization of biologics such as therapeutic antibodies and RNA‐based therapeutic agents, this article focuses on small molecule drugs. Applications of mass spectrometry to drug discovery include support for combinatorial chemistry, mass spectrometry‐based high‐throughput screening, and lead optimization. In the case of natural products, mass spectrometry facilitates rapid and accurate activity screening, characterization, dereplication, and identification of active compounds. Mass spectrometry provides rapid, reliable, sensitive, and selective analysis of combinatorial libraries for structure confirmation, purity analysis, and library deconvolution. In addition, mass spectrometric screening methods have been developed and applied to drug discovery and development. In support of drug development, high‐throughput LC‐MS methods have become routine for solubility and bioavailability testing and metabolite screening to ensure that only high‐quality lead compounds are advanced to expensive clinical testing." @default.
- W4245871013 created "2022-05-12" @default.
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- W4245871013 date "2021-04-26" @default.
- W4245871013 modified "2023-10-16" @default.
- W4245871013 title "Mass Spectrometry and Drug Discovery" @default.
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- W4245871013 doi "https://doi.org/10.1002/0471266949.bmc012.pub3" @default.
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