Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245908051> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4245908051 endingPage "3251" @default.
- W4245908051 startingPage "3240" @default.
- W4245908051 abstract "The role of nerve growth factor (NGF), a potent mediator acting in the development and differentitation of both neuronal and immune cells, was examined in a mouse model of allergic asthma. NGF-positive cells were detected in the inflammatory infiltrate of the lung and enhanced levels of NGF were detected in serum and broncho-alveolar lavage fluids. Mononuclear cells in inflamed airway mucosa as well as broncho-alveolar macrophages were identified as one source of NGF production. Splenic mononuclear cells from allergen-sensitized mice produced NGF in response to allergen. They responded to exogenously added NGF with a dose-dependent increase in IL-4 and IL-5 production and augmented IgE and IgG1 synthesis. In contrast, IFN-γ and IgG2a levels remained unaffected. The effects were NGF specific, since they could be blocked by an anti-NGF-antibody. Nasal application of anti-NGF to allergen-sensitized mice significantly reduced IL-4 and prevented development of airway hyperreactivity. These results show that allergic airway inflammation is accompanied by enhanced local NGF production that acts as an amplifier for Th2 effector functions and plays an important role in the development of airway hyperreactivity. Therefore it is suggested that NGF may serve as a link between the immune and nerve system." @default.
- W4245908051 created "2022-05-12" @default.
- W4245908051 creator A5030443636 @default.
- W4245908051 creator A5042816885 @default.
- W4245908051 creator A5049510710 @default.
- W4245908051 creator A5053003825 @default.
- W4245908051 creator A5053801647 @default.
- W4245908051 creator A5071979955 @default.
- W4245908051 creator A5082322510 @default.
- W4245908051 creator A5090650222 @default.
- W4245908051 date "1998-10-01" @default.
- W4245908051 modified "2023-10-01" @default.
- W4245908051 title "Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma" @default.
- W4245908051 doi "https://doi.org/10.1002/(sici)1521-4141(199810)28:10<3240::aid-immu3240>3.3.co;2-l" @default.
- W4245908051 hasPublicationYear "1998" @default.
- W4245908051 type Work @default.
- W4245908051 citedByCount "1" @default.
- W4245908051 crossrefType "journal-article" @default.
- W4245908051 hasAuthorship W4245908051A5030443636 @default.
- W4245908051 hasAuthorship W4245908051A5042816885 @default.
- W4245908051 hasAuthorship W4245908051A5049510710 @default.
- W4245908051 hasAuthorship W4245908051A5053003825 @default.
- W4245908051 hasAuthorship W4245908051A5053801647 @default.
- W4245908051 hasAuthorship W4245908051A5071979955 @default.
- W4245908051 hasAuthorship W4245908051A5082322510 @default.
- W4245908051 hasAuthorship W4245908051A5090650222 @default.
- W4245908051 hasBestOaLocation W42459080511 @default.
- W4245908051 hasConcept C105922876 @default.
- W4245908051 hasConcept C126322002 @default.
- W4245908051 hasConcept C137061746 @default.
- W4245908051 hasConcept C141105273 @default.
- W4245908051 hasConcept C159654299 @default.
- W4245908051 hasConcept C170493617 @default.
- W4245908051 hasConcept C202751555 @default.
- W4245908051 hasConcept C203014093 @default.
- W4245908051 hasConcept C2776914184 @default.
- W4245908051 hasConcept C2778423431 @default.
- W4245908051 hasConcept C2779675166 @default.
- W4245908051 hasConcept C42219234 @default.
- W4245908051 hasConcept C55493867 @default.
- W4245908051 hasConcept C71924100 @default.
- W4245908051 hasConcept C86803240 @default.
- W4245908051 hasConcept C8891405 @default.
- W4245908051 hasConceptScore W4245908051C105922876 @default.
- W4245908051 hasConceptScore W4245908051C126322002 @default.
- W4245908051 hasConceptScore W4245908051C137061746 @default.
- W4245908051 hasConceptScore W4245908051C141105273 @default.
- W4245908051 hasConceptScore W4245908051C159654299 @default.
- W4245908051 hasConceptScore W4245908051C170493617 @default.
- W4245908051 hasConceptScore W4245908051C202751555 @default.
- W4245908051 hasConceptScore W4245908051C203014093 @default.
- W4245908051 hasConceptScore W4245908051C2776914184 @default.
- W4245908051 hasConceptScore W4245908051C2778423431 @default.
- W4245908051 hasConceptScore W4245908051C2779675166 @default.
- W4245908051 hasConceptScore W4245908051C42219234 @default.
- W4245908051 hasConceptScore W4245908051C55493867 @default.
- W4245908051 hasConceptScore W4245908051C71924100 @default.
- W4245908051 hasConceptScore W4245908051C86803240 @default.
- W4245908051 hasConceptScore W4245908051C8891405 @default.
- W4245908051 hasIssue "10" @default.
- W4245908051 hasLocation W42459080511 @default.
- W4245908051 hasOpenAccess W4245908051 @default.
- W4245908051 hasPrimaryLocation W42459080511 @default.
- W4245908051 hasRelatedWork W1988025298 @default.
- W4245908051 hasRelatedWork W2012938450 @default.
- W4245908051 hasRelatedWork W2024030696 @default.
- W4245908051 hasRelatedWork W2041967174 @default.
- W4245908051 hasRelatedWork W2086871979 @default.
- W4245908051 hasRelatedWork W2093870599 @default.
- W4245908051 hasRelatedWork W2103469863 @default.
- W4245908051 hasRelatedWork W2116870945 @default.
- W4245908051 hasRelatedWork W2167755986 @default.
- W4245908051 hasRelatedWork W5456082 @default.
- W4245908051 hasVolume "28" @default.
- W4245908051 isParatext "false" @default.
- W4245908051 isRetracted "false" @default.
- W4245908051 workType "article" @default.