Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245958271> ?p ?o ?g. }
- W4245958271 endingPage "568" @default.
- W4245958271 startingPage "561" @default.
- W4245958271 abstract "Inorganic phosphate is essential for ECM mineralization and also as a constituent of important molecules in cellular metabolism. Investigations of several hypophosphatemic diseases indicated that a hormone-like molecule probably regulates serum phosphate concentration. FGF23 has recently been recognized as playing important pathophysiological roles in several hypophosphatemic diseases. We present here the evidence that FGF23 is a physiological regulator of serum phosphate and 1,25-dihydroxyvitamin D (1,25[OH]2D) by generating FGF23-null mice. Disruption of the Fgf23 gene did not result in embryonic lethality, although homozygous mice showed severe growth retardation with abnormal bone phenotype and markedly short life span. The Fgf23–/– mice displayed significantly high serum phosphate with increased renal phosphate reabsorption. They also showed an elevation in serum 1,25(OH)2D that was due to the enhanced expression of renal 25-hydroxyvitamin D-1α-hydroxylase (1α-OHase) from 10 days of age. These phenotypes could not be explained by currently known regulators of mineral homeostasis, indicating that FGF23 is essential for normal phosphate and vitamin D metabolism." @default.
- W4245958271 created "2022-05-12" @default.
- W4245958271 creator A5002923621 @default.
- W4245958271 creator A5003548270 @default.
- W4245958271 creator A5009151280 @default.
- W4245958271 creator A5010247416 @default.
- W4245958271 creator A5017039765 @default.
- W4245958271 creator A5023330443 @default.
- W4245958271 creator A5046784299 @default.
- W4245958271 creator A5080266991 @default.
- W4245958271 creator A5089996469 @default.
- W4245958271 date "2004-02-15" @default.
- W4245958271 modified "2023-10-14" @default.
- W4245958271 title "Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism" @default.
- W4245958271 cites W1525820657 @default.
- W4245958271 cites W1563425273 @default.
- W4245958271 cites W1970305413 @default.
- W4245958271 cites W1973319487 @default.
- W4245958271 cites W2000004275 @default.
- W4245958271 cites W2009441758 @default.
- W4245958271 cites W2018381121 @default.
- W4245958271 cites W2020138048 @default.
- W4245958271 cites W2029056840 @default.
- W4245958271 cites W2039179580 @default.
- W4245958271 cites W2059629870 @default.
- W4245958271 cites W2063460615 @default.
- W4245958271 cites W2068226571 @default.
- W4245958271 cites W2075357551 @default.
- W4245958271 cites W2077344034 @default.
- W4245958271 cites W2094262605 @default.
- W4245958271 cites W2109177164 @default.
- W4245958271 cites W2164952534 @default.
- W4245958271 cites W2170351820 @default.
- W4245958271 cites W4236241020 @default.
- W4245958271 cites W4252531423 @default.
- W4245958271 cites W4256049800 @default.
- W4245958271 doi "https://doi.org/10.1172/jci200419081" @default.
- W4245958271 hasPublicationYear "2004" @default.
- W4245958271 type Work @default.
- W4245958271 citedByCount "1138" @default.
- W4245958271 countsByYear W42459582712012 @default.
- W4245958271 countsByYear W42459582712013 @default.
- W4245958271 countsByYear W42459582712014 @default.
- W4245958271 countsByYear W42459582712015 @default.
- W4245958271 countsByYear W42459582712016 @default.
- W4245958271 countsByYear W42459582712017 @default.
- W4245958271 countsByYear W42459582712018 @default.
- W4245958271 countsByYear W42459582712019 @default.
- W4245958271 countsByYear W42459582712020 @default.
- W4245958271 countsByYear W42459582712021 @default.
- W4245958271 countsByYear W42459582712022 @default.
- W4245958271 countsByYear W42459582712023 @default.
- W4245958271 crossrefType "journal-article" @default.
- W4245958271 hasAuthorship W4245958271A5002923621 @default.
- W4245958271 hasAuthorship W4245958271A5003548270 @default.
- W4245958271 hasAuthorship W4245958271A5009151280 @default.
- W4245958271 hasAuthorship W4245958271A5010247416 @default.
- W4245958271 hasAuthorship W4245958271A5017039765 @default.
- W4245958271 hasAuthorship W4245958271A5023330443 @default.
- W4245958271 hasAuthorship W4245958271A5046784299 @default.
- W4245958271 hasAuthorship W4245958271A5080266991 @default.
- W4245958271 hasAuthorship W4245958271A5089996469 @default.
- W4245958271 hasBestOaLocation W42459582711 @default.
- W4245958271 hasConcept C114276007 @default.
- W4245958271 hasConcept C124490489 @default.
- W4245958271 hasConcept C126322002 @default.
- W4245958271 hasConcept C134018914 @default.
- W4245958271 hasConcept C170033053 @default.
- W4245958271 hasConcept C2776338720 @default.
- W4245958271 hasConcept C2776489590 @default.
- W4245958271 hasConcept C2776940978 @default.
- W4245958271 hasConcept C2777132085 @default.
- W4245958271 hasConcept C2778573388 @default.
- W4245958271 hasConcept C2780091579 @default.
- W4245958271 hasConcept C2781208988 @default.
- W4245958271 hasConcept C2911197707 @default.
- W4245958271 hasConcept C519063684 @default.
- W4245958271 hasConcept C55493867 @default.
- W4245958271 hasConcept C56906281 @default.
- W4245958271 hasConcept C62231903 @default.
- W4245958271 hasConcept C63645605 @default.
- W4245958271 hasConcept C71924100 @default.
- W4245958271 hasConcept C86803240 @default.
- W4245958271 hasConceptScore W4245958271C114276007 @default.
- W4245958271 hasConceptScore W4245958271C124490489 @default.
- W4245958271 hasConceptScore W4245958271C126322002 @default.
- W4245958271 hasConceptScore W4245958271C134018914 @default.
- W4245958271 hasConceptScore W4245958271C170033053 @default.
- W4245958271 hasConceptScore W4245958271C2776338720 @default.
- W4245958271 hasConceptScore W4245958271C2776489590 @default.
- W4245958271 hasConceptScore W4245958271C2776940978 @default.
- W4245958271 hasConceptScore W4245958271C2777132085 @default.
- W4245958271 hasConceptScore W4245958271C2778573388 @default.
- W4245958271 hasConceptScore W4245958271C2780091579 @default.
- W4245958271 hasConceptScore W4245958271C2781208988 @default.
- W4245958271 hasConceptScore W4245958271C2911197707 @default.
- W4245958271 hasConceptScore W4245958271C519063684 @default.
- W4245958271 hasConceptScore W4245958271C55493867 @default.