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• W4245965665 abstract "AbstractThe enzyme 3β-hydroxysteroid dehydrogenase plays a crucial role in the steroidogenic process in the adrenal gland. In the present study we tried to characterize its localization and developmental changes in the rat adrenal cortex during the postnatal period, using immunohistochemical methods. The development of the different zones evidenced specific particularities: the zona glomerulosa almost lacked 3β-HSD in the first days after birth; then, 3β-HSD increased, attaining a maximum around day 20 and afterwards it decreased again and remained less intense than the neighbouring zona fasciculata up until adulthood (65 days of age). The zona fasciculata was already intensely stained at birth and the expression of 3β-HSD increased rapidly reaching a maximum after 2 weeks of life and that level was maintained from then on. The inner part of the zona fasciculata and the zona reticularis both of which develop postnatally were faintly immunostained before day 20. The expression of 3β-HSD increased after that age to become approximately as intense as in the outer zona fasciculata and so remaining until day 90. The development of the zona glomerulosa was parallel to the secretion of aldosterone. The same did not occur with the zona fasciculata as the intensity of staining during the first 14 postnatal days was accompanied by very low levels of corticosterone." @default.
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• W4245965665 date "1999-02-01" @default.
• W4245965665 modified "2023-10-18" @default.
• W4245965665 title "Ontogeny of 3β-Hydroxystfroid Dehydrogenase Expression in the Rat Adrenal Gland as Studied by Immunohistochemistry" @default.
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• W4245965665 doi "https://doi.org/10.1080/07435809909066126" @default.
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