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- W4245981608 abstract "Although morbidity and mortality are improving, heart failure continues to present major challenges to healthcare systems. This affliction of mainly the elderly may be falling in incidence but is probably growing in prevalence, in part due to greater longevity resulting from evidence-based drug and device therapy for patients with a low ejection fraction (EF). New guidelines emphasize the combination of an angiotensin-converting enzyme inhibitor and beta-blocker as the cornerstone of therapy, with the addition of either an angiotensin receptor blocker or aldosterone antagonist as the third disease-modifying agent in patients who remain symptomatic. An implanted cardioverter defibrillator should also be added in patients with a persistently low EF and life expectancy of reasonable quality of ≥12 months. In patients in sinus rhythm, New York Heart Association class III–IV, and a QRS duration ≥120ms, cardiac resynchronization therapy has substantial additional morbidity and mortality benefits. This evidence-based care should be delivered through an organized and seamless multidisciplinary framework with a focus on the patients’ and carers’ needs. Apart from transplantation, the place of any other surgical intervention remains uncertain. Unfortunately the success of treatment in low EF heart failure has not been replicated in patients with heart failure and a preserved EF, and treatment of these patients remains empirical. The same is largely true for the treatment of patients with acute heart failure, with no treatment yet shown to be superior to empirical therapy with diuretic, oxygen, and nitrates. In particular the role of inotropes remains uncertain...." @default.
- W4245981608 created "2022-05-12" @default.
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- W4245981608 date "2009-08-01" @default.
- W4245981608 modified "2023-09-26" @default.
- W4245981608 title "Heart Failure" @default.
- W4245981608 cites W104425974 @default.
- W4245981608 cites W1414418298 @default.
- W4245981608 cites W1418063743 @default.
- W4245981608 cites W1488720446 @default.
- W4245981608 cites W1491329651 @default.
- W4245981608 cites W1543680891 @default.
- W4245981608 cites W170303893 @default.
- W4245981608 cites W1856550782 @default.
- W4245981608 cites W1929022162 @default.
- W4245981608 cites W1963486489 @default.
- W4245981608 cites W1964714332 @default.
- W4245981608 cites W1964925711 @default.
- W4245981608 cites W1965000519 @default.
- W4245981608 cites W1965619583 @default.
- W4245981608 cites W1966182783 @default.
- W4245981608 cites W1967251000 @default.
- W4245981608 cites W1967369828 @default.
- W4245981608 cites W1967418231 @default.
- W4245981608 cites W1967872325 @default.
- W4245981608 cites W1967986324 @default.
- W4245981608 cites W1970134098 @default.
- W4245981608 cites W1970151280 @default.
- W4245981608 cites W1970925455 @default.
- W4245981608 cites W1971240641 @default.
- W4245981608 cites W1971505725 @default.
- W4245981608 cites W1971511999 @default.
- W4245981608 cites W1971581232 @default.
- W4245981608 cites W1973770406 @default.
- W4245981608 cites W1975603373 @default.
- W4245981608 cites W1976132052 @default.
- W4245981608 cites W1977390046 @default.
- W4245981608 cites W1977390656 @default.
- W4245981608 cites W1979711232 @default.
- W4245981608 cites W1979792137 @default.
- W4245981608 cites W1982863476 @default.
- W4245981608 cites W1985031042 @default.
- W4245981608 cites W1985724766 @default.
- W4245981608 cites W1985760052 @default.
- W4245981608 cites W1986523461 @default.
- W4245981608 cites W1993420218 @default.
- W4245981608 cites W1993606481 @default.
- W4245981608 cites W1993848345 @default.
- W4245981608 cites W1994001852 @default.
- W4245981608 cites W1994394104 @default.
- W4245981608 cites W1994497410 @default.
- W4245981608 cites W1994664158 @default.
- W4245981608 cites W1994835493 @default.
- W4245981608 cites W1995426124 @default.
- W4245981608 cites W1995445699 @default.
- W4245981608 cites W1996370109 @default.
- W4245981608 cites W1997780004 @default.
- W4245981608 cites W1998658944 @default.
- W4245981608 cites W2004782018 @default.
- W4245981608 cites W2005177820 @default.
- W4245981608 cites W2005405415 @default.
- W4245981608 cites W2006408633 @default.
- W4245981608 cites W2006864501 @default.
- W4245981608 cites W2007497986 @default.
- W4245981608 cites W2007946529 @default.
- W4245981608 cites W2008896976 @default.
- W4245981608 cites W2009741254 @default.
- W4245981608 cites W2010032368 @default.
- W4245981608 cites W2010594476 @default.
- W4245981608 cites W2010983847 @default.
- W4245981608 cites W2012574332 @default.
- W4245981608 cites W2014487773 @default.
- W4245981608 cites W2015244007 @default.
- W4245981608 cites W2016818962 @default.
- W4245981608 cites W2017383334 @default.
- W4245981608 cites W2017666800 @default.
- W4245981608 cites W2018271295 @default.
- W4245981608 cites W2018522628 @default.
- W4245981608 cites W2018877732 @default.
- W4245981608 cites W2019694810 @default.
- W4245981608 cites W2020009596 @default.
- W4245981608 cites W2020468542 @default.
- W4245981608 cites W2021785033 @default.
- W4245981608 cites W2023515446 @default.
- W4245981608 cites W2026232211 @default.
- W4245981608 cites W2026548865 @default.
- W4245981608 cites W2026881482 @default.
- W4245981608 cites W2028139057 @default.
- W4245981608 cites W2031574191 @default.
- W4245981608 cites W2032788813 @default.
- W4245981608 cites W2033989169 @default.
- W4245981608 cites W2035667813 @default.
- W4245981608 cites W2036718044 @default.