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• W4245991566 abstract "Schmitt, J et al. Allergy. 2019; 75: 596–602. https://doi.org/10.1111/all.14020 The effect of allergy immunotherapy (AIT) on the development of asthma from mild to more severe was studied in this population-based cohort study in Germany. Over 1.7 million asthmatics were included, 10% of whom received AIT. AIT was associated with a significant decrease in the probability of asthma severity worsening, particularly from GINA (global initiative for asthma) treatment step 1–3 (hazard ratio 0.87, 95% CI 0.8–0.95). Bawany F et al. J Allergy Clin Immunol Pract 2020;8:860–75. https://doi.org/10.1016/j.jaip.2019.12.005 When first exploring the area of allergy prevention, it’s easy to get lost within the plethora of studies that have assessed potential risk factors and preventative interventions for the onset of allergic disease. This review from KirsiJarvinen’s group provides a helpful overview of the key knowns and unknowns within the current research landscape. Following extensive literature review the authors provide a balanced commentary on the outcomes from the most recent seminal studies which have assessed a multitude of potential environmental risk factors for eczema and food allergy/sensitisation including early emollient use, microbiome, breastfeeding, vitamin D, water hardness and immunotherapy. Certainly a helpful roadmap to further reading. Simpson, Angela et al. Journal of Allergy and Clinical Immunology, Volume 145, Issue 3, 993–1001 https://doi.org/10.1016/j.jaci.2019.08.041 In this population-based cohort study, mite, cat and dog allergen levels in household dust were collected in the first year of life and sensitisation to these allergens measured on six occasions from infancy to age 16. Genotyping was also performed to six FLG mutations. A significant association was observed between FLG mutations, Fel d1 sensitisation and cat exposure. Of interest, children with FLG mutations were who exposed to dogs in infancy were less likely to be sensitised to any allergen (OR 0.16; 95% CI 0.03–0.86; P = .03) which is consistent with other studies suggesting a protective effect of early dog exposure. Cardona ID et al. J Allergy Clin Immunol Pract 2020;8:1014–21 https://doi.org/10.1016/j.jaip.2019.10.042 The variation in advice provided to parents on the optimal frequency of bathing children with atopic dermatitis arises from the lack of clear randomised control trial data in this area. In this article Ivan Cardona et al present findings from their prospective single-blinded randomised cross-over control trial, where children aged 7–11 year with atopic dermatitis received a fortnight of twice weekly or twice daily bathing in a cross-over design. SCORing Atopic Dermatitis (SCORAD) index was compared between interventions and a significantly lower SCORAD with twice daily bathing is noted." @default.
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• W4245991566 date "2020-04-29" @default.
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