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- W4246013312 abstract "This chapter offers a contemporary approach to the classification of diseases of skeletal muscle and describes and illustrates the pathology of muscle disease, particularly from the perspective of the muscle biopsy. After an introductory exposition of the relevant laboratory techniques and a synopsis of the normal appearance of skeletal muscle, the basic reactions to injury are described. The ranges of diseases of skeletal muscle are then systematically considered and their specific morphologic, biochemical, and molecular genetic abnormalities are discussed in detail. The approach is to subdivide muscle disease into two broad categories: conditions that result in denervation of muscle (i.e., neurogenic atrophy) and diseases where the primary abnormality is in the muscle cell itself (i.e. myopathies). Genetically determined diseases of skeletal muscle discussed include muscular dystrophies, congenital myopathies, myofibrillar myopathies, and metabolic myopathies. Next described are the inflammatory myopathies, which are divided into two groups according to whether the causative agent is a known microorganisms or whether the inflammatory process is believed to be an autoimmune phenomenon." @default.
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- W4246013312 date "2013-12-01" @default.
- W4246013312 modified "2023-09-24" @default.
- W4246013312 title "Pathology of Skeletal Muscle" @default.
- W4246013312 doi "https://doi.org/10.1093/med/9780199929054.003.0012" @default.
- W4246013312 hasPublicationYear "2013" @default.
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