Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246020917> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4246020917 endingPage "278" @default.
- W4246020917 startingPage "273" @default.
- W4246020917 abstract "Vincristine is an anticancer agent that continues to be examined in preclinical models even though it is used in a variety of human neoplastic disorders. We developed a sensitive liquid chromatography–mass spectrometry (LC–MS) method for the determination of vincristine in plasma and in brain tissues that would support investigations on drug distribution into tissues in animal models. The procedure required only a small sample volume (10 μl) of plasma, which circumvented a limitation of most other assays that were developed for human samples. A solid-phase extraction procedure was employed that enabled the eluent to be directly injected onto a reversed-phase chromatographic HPLC system using positive electrospray ionization followed by mass spectrometric detection. The extraction recoveries of vincristine were 57 and 60% from plasma and brain tissues, respectively. The mobile phase consisted of methanol and 15 mM ammonium acetate in 0.02% formic acid (70:30) that was pumped at 0.2 ml/min to yield retention times of 1.6 and 1.8 min for vincristine and vinblastine, the internal standard, respectively. The method was validated at vincristine plasma concentrations from 0.01 to 2 μg/ml, and from 0.01 to 1 μg/g in brain tissue. The advantage of the method enabled the quantitation of vincristine in multiple plasma samples obtained from a single mouse, which permitted the accurate estimation of its pharmacokinetic properties." @default.
- W4246020917 created "2022-05-12" @default.
- W4246020917 creator A5000800861 @default.
- W4246020917 creator A5044140793 @default.
- W4246020917 creator A5056500955 @default.
- W4246020917 creator A5077211257 @default.
- W4246020917 date "2004-10-05" @default.
- W4246020917 modified "2023-10-11" @default.
- W4246020917 title "Determination of vincristine in mouse plasma and brain tissues by liquid chromatography–electrospray mass spectrometry" @default.
- W4246020917 doi "https://doi.org/10.1016/s1570-0232(04)00508-2" @default.
- W4246020917 hasPublicationYear "2004" @default.
- W4246020917 type Work @default.
- W4246020917 citedByCount "18" @default.
- W4246020917 countsByYear W42460209172013 @default.
- W4246020917 countsByYear W42460209172015 @default.
- W4246020917 countsByYear W42460209172016 @default.
- W4246020917 countsByYear W42460209172018 @default.
- W4246020917 countsByYear W42460209172021 @default.
- W4246020917 countsByYear W42460209172022 @default.
- W4246020917 crossrefType "journal-article" @default.
- W4246020917 hasAuthorship W4246020917A5000800861 @default.
- W4246020917 hasAuthorship W4246020917A5044140793 @default.
- W4246020917 hasAuthorship W4246020917A5056500955 @default.
- W4246020917 hasAuthorship W4246020917A5077211257 @default.
- W4246020917 hasConcept C112705442 @default.
- W4246020917 hasConcept C141071460 @default.
- W4246020917 hasConcept C162356407 @default.
- W4246020917 hasConcept C179998833 @default.
- W4246020917 hasConcept C185592680 @default.
- W4246020917 hasConcept C194451485 @default.
- W4246020917 hasConcept C2776694085 @default.
- W4246020917 hasConcept C2776755627 @default.
- W4246020917 hasConcept C2777379063 @default.
- W4246020917 hasConcept C2779429289 @default.
- W4246020917 hasConcept C2780782300 @default.
- W4246020917 hasConcept C31827203 @default.
- W4246020917 hasConcept C40684141 @default.
- W4246020917 hasConcept C43617362 @default.
- W4246020917 hasConcept C4725764 @default.
- W4246020917 hasConcept C71043704 @default.
- W4246020917 hasConcept C71924100 @default.
- W4246020917 hasConcept C95986675 @default.
- W4246020917 hasConcept C98274493 @default.
- W4246020917 hasConceptScore W4246020917C112705442 @default.
- W4246020917 hasConceptScore W4246020917C141071460 @default.
- W4246020917 hasConceptScore W4246020917C162356407 @default.
- W4246020917 hasConceptScore W4246020917C179998833 @default.
- W4246020917 hasConceptScore W4246020917C185592680 @default.
- W4246020917 hasConceptScore W4246020917C194451485 @default.
- W4246020917 hasConceptScore W4246020917C2776694085 @default.
- W4246020917 hasConceptScore W4246020917C2776755627 @default.
- W4246020917 hasConceptScore W4246020917C2777379063 @default.
- W4246020917 hasConceptScore W4246020917C2779429289 @default.
- W4246020917 hasConceptScore W4246020917C2780782300 @default.
- W4246020917 hasConceptScore W4246020917C31827203 @default.
- W4246020917 hasConceptScore W4246020917C40684141 @default.
- W4246020917 hasConceptScore W4246020917C43617362 @default.
- W4246020917 hasConceptScore W4246020917C4725764 @default.
- W4246020917 hasConceptScore W4246020917C71043704 @default.
- W4246020917 hasConceptScore W4246020917C71924100 @default.
- W4246020917 hasConceptScore W4246020917C95986675 @default.
- W4246020917 hasConceptScore W4246020917C98274493 @default.
- W4246020917 hasIssue "2" @default.
- W4246020917 hasLocation W42460209171 @default.
- W4246020917 hasOpenAccess W4246020917 @default.
- W4246020917 hasPrimaryLocation W42460209171 @default.
- W4246020917 hasRelatedWork W1277187992 @default.
- W4246020917 hasRelatedWork W1558772439 @default.
- W4246020917 hasRelatedWork W1995099079 @default.
- W4246020917 hasRelatedWork W2014605936 @default.
- W4246020917 hasRelatedWork W2069138744 @default.
- W4246020917 hasRelatedWork W2148112117 @default.
- W4246020917 hasRelatedWork W2517618103 @default.
- W4246020917 hasRelatedWork W2972429458 @default.
- W4246020917 hasRelatedWork W2980563832 @default.
- W4246020917 hasRelatedWork W4238213830 @default.
- W4246020917 hasVolume "809" @default.
- W4246020917 isParatext "false" @default.
- W4246020917 isRetracted "false" @default.
- W4246020917 workType "article" @default.