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- W4246043893 abstract "BACKGROUND Although α-adrenergic blockers are widely used as a treatment of benign prostatic hyperplasia (BPH), it is not clear whether contractile property of hyperplastic prostate to α-adrenergic agonist depends upon an area of density of smooth muscle within the respective BPH tissue. METHODS Functional study and quantitative morphometric analysis were performed on human prostatic specimens obtained by transurethral resection from 22 men with symptomatic BPH. Tissue norepinephrine content was also evaluated. RESULTS There was a linear correlation between the area of density of smooth muscle and maximum response to phenylephrine (r = 0.457, P = 0.0362). Although the area of density of smooth muscle showed a positive correlation with norepinephrine content (r = 0.437, P = 0.0471), norepinephrine content was not correlated with maximum phenylephrine response. CONCLUSIONS Contractile response to α-adrenergic agonist was directly influenced by the area of density of the smooth muscle within an individual prostate. Prostate 33:183–187, 1997. © 1997 Wiley-Liss, Inc." @default.
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- W4246043893 date "1997-11-01" @default.
- W4246043893 modified "2023-09-27" @default.
- W4246043893 title "Functional property, norepinephrine content and morphometric findings in human hyperplastic prostate" @default.
- W4246043893 doi "https://doi.org/10.1002/(sici)1097-0045(19971101)33:3<183::aid-pros6>3.3.co;2-0" @default.
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