Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246062672> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4246062672 abstract "Abstract Background: Genetic factors such as single nucleotide polymorphisms (SNPs) play a key role in the development of postoperative nausea and vomiting (PONV). However, previous findings are not widely applicable to different populations because of population-specific genetic variation. We developed a Japanese-specific DNA microarray for high-throughput genotyping. The aim of the current study is to identify causal SNPs associated with PONV on a genome-wide scale using this microarray in a sample of Japanese surgical patients. associations between 659,636 SNPs and the incidence of PONV 24 h after surgery in a limited sample of 24 female patients using the microarray. After imputation of genotypes at 24,330,529 SNPs, 78 SNPs were found to be associated with the incidence of PONV. We chose 4 of the 78 SNPs to focus on by in silico functional annotation. Finally, we genotyped these 4 candidate SNPs in 255 patients using real-time PCR to verify association with the incidence of PONV. Results: The T > C variant of rs11232965 in the long non-coding RNA MIR4300HG was significantly associated with reduced incidence of PONV among genotypes and between alleles (p = 0.01 and 0.007). Conclusions: We identified a novel causal SNP (rs11232965) in the long non-coding RNA MIR4300HG that is associated with PONV. The rs11232965-SNP variant (T > C) is protective against the incidence of PONV. Trial registration: This study was registered at the UMIN Clinical Trials Registry (Identifier: UMIN000022903, date of registration: June 27th, 2016, retrospectively registered, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026392)." @default.
- W4246062672 created "2022-05-12" @default.
- W4246062672 creator A5006257540 @default.
- W4246062672 creator A5014497076 @default.
- W4246062672 creator A5025220924 @default.
- W4246062672 creator A5028891162 @default.
- W4246062672 creator A5032181116 @default.
- W4246062672 creator A5033712820 @default.
- W4246062672 creator A5052862455 @default.
- W4246062672 creator A5071067330 @default.
- W4246062672 creator A5075847152 @default.
- W4246062672 creator A5076214743 @default.
- W4246062672 creator A5077084563 @default.
- W4246062672 creator A5079896955 @default.
- W4246062672 creator A5084500628 @default.
- W4246062672 creator A5088667844 @default.
- W4246062672 creator A5088759928 @default.
- W4246062672 date "2020-06-18" @default.
- W4246062672 modified "2023-09-29" @default.
- W4246062672 title "Long non-coding RNA MIR4300HG polymorphisms are associated with postoperative nausea and vomiting: a genome-wide association study" @default.
- W4246062672 doi "https://doi.org/10.21203/rs.3.rs-21047/v2" @default.
- W4246062672 hasPublicationYear "2020" @default.
- W4246062672 type Work @default.
- W4246062672 citedByCount "0" @default.
- W4246062672 crossrefType "posted-content" @default.
- W4246062672 hasAuthorship W4246062672A5006257540 @default.
- W4246062672 hasAuthorship W4246062672A5014497076 @default.
- W4246062672 hasAuthorship W4246062672A5025220924 @default.
- W4246062672 hasAuthorship W4246062672A5028891162 @default.
- W4246062672 hasAuthorship W4246062672A5032181116 @default.
- W4246062672 hasAuthorship W4246062672A5033712820 @default.
- W4246062672 hasAuthorship W4246062672A5052862455 @default.
- W4246062672 hasAuthorship W4246062672A5071067330 @default.
- W4246062672 hasAuthorship W4246062672A5075847152 @default.
- W4246062672 hasAuthorship W4246062672A5076214743 @default.
- W4246062672 hasAuthorship W4246062672A5077084563 @default.
- W4246062672 hasAuthorship W4246062672A5079896955 @default.
- W4246062672 hasAuthorship W4246062672A5084500628 @default.
- W4246062672 hasAuthorship W4246062672A5088667844 @default.
- W4246062672 hasAuthorship W4246062672A5088759928 @default.
- W4246062672 hasBestOaLocation W42460626721 @default.
- W4246062672 hasConcept C104317684 @default.
- W4246062672 hasConcept C106208931 @default.
- W4246062672 hasConcept C135763542 @default.
- W4246062672 hasConcept C139275648 @default.
- W4246062672 hasConcept C153209595 @default.
- W4246062672 hasConcept C163691529 @default.
- W4246062672 hasConcept C186413461 @default.
- W4246062672 hasConcept C31467283 @default.
- W4246062672 hasConcept C54355233 @default.
- W4246062672 hasConcept C60644358 @default.
- W4246062672 hasConcept C71924100 @default.
- W4246062672 hasConcept C86803240 @default.
- W4246062672 hasConcept C97425143 @default.
- W4246062672 hasConceptScore W4246062672C104317684 @default.
- W4246062672 hasConceptScore W4246062672C106208931 @default.
- W4246062672 hasConceptScore W4246062672C135763542 @default.
- W4246062672 hasConceptScore W4246062672C139275648 @default.
- W4246062672 hasConceptScore W4246062672C153209595 @default.
- W4246062672 hasConceptScore W4246062672C163691529 @default.
- W4246062672 hasConceptScore W4246062672C186413461 @default.
- W4246062672 hasConceptScore W4246062672C31467283 @default.
- W4246062672 hasConceptScore W4246062672C54355233 @default.
- W4246062672 hasConceptScore W4246062672C60644358 @default.
- W4246062672 hasConceptScore W4246062672C71924100 @default.
- W4246062672 hasConceptScore W4246062672C86803240 @default.
- W4246062672 hasConceptScore W4246062672C97425143 @default.
- W4246062672 hasLocation W42460626721 @default.
- W4246062672 hasLocation W42460626722 @default.
- W4246062672 hasLocation W42460626723 @default.
- W4246062672 hasOpenAccess W4246062672 @default.
- W4246062672 hasPrimaryLocation W42460626721 @default.
- W4246062672 hasRelatedWork W1663907732 @default.
- W4246062672 hasRelatedWork W2027381516 @default.
- W4246062672 hasRelatedWork W2042127480 @default.
- W4246062672 hasRelatedWork W2076132083 @default.
- W4246062672 hasRelatedWork W2095322240 @default.
- W4246062672 hasRelatedWork W2100429291 @default.
- W4246062672 hasRelatedWork W2145474755 @default.
- W4246062672 hasRelatedWork W2788730786 @default.
- W4246062672 hasRelatedWork W2791888721 @default.
- W4246062672 hasRelatedWork W2508339930 @default.
- W4246062672 isParatext "false" @default.
- W4246062672 isRetracted "false" @default.
- W4246062672 workType "article" @default.