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- W42460657 abstract "Normal pregnancy modifies every aspect of maternal intermediary metabolism. The realignments of the fasted State may be characterized as “accelerated starvation” and the changes in the fed State may “facilitate anabolism”. These alterations in fuel economy contribute to the post-receptor insulin resistance of normal pregnancy and must be appreciated in any approaches to the management of pregnancies complicated by diabetes. Recent attention has focused on the implications of maternal fuel metabolism for intrauterine development in so far as maternal fuels delimit the “tissue culture medium” in which the new cells of the conceptus are formed and undergo Organization, differentiation and functional maturation. Neonatal characteristics of the off spring have been clearly linked to the antepartum metabolism of the mother and the exquisitely sensitive relationships to maternal insulinization have now been documented. Mounting evidence is also identifying the potentiality for more long-range effects of maternal metabolism. These appear to be mediated via fuel-related modifications of genetic expression during organogenesis in the embryo and during the development of terminally-differentiated cells in the fetus (i.e. “fuel-mediated teratogenesis”). As a consequence, permanent alterations may occur in behavioral, intellectual, metabolic, anthropometric and other phenotypic characteristics of the offspring. The long-range possibilities provide even more compelling reasons for attempts to normalize maternal metabolism during pregnancies complicated by diabetes or other perturbations of fuel homeostasis. They also underscore that diabetes in pregnancy may serve as a paradigm of the relationships that obtain between maternal fuel economy and developmental biology in all pregnancies." @default.
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- W42460657 date "1987-01-01" @default.
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- W42460657 title "Implications of Diabetes in Pregnancy for Developmental Biology" @default.
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- W42460657 doi "https://doi.org/10.1007/978-3-642-85460-6_60" @default.
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