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- W4246098983 abstract "The study of childhood psychiatric disorders is especially challenging, not only because of the difficulties in obtaining relevant human samples but also because of ethical considerations regarding the ability of children to provide informed consent. Models that can be experimentally manipulated are therefore indispensable to study those disorders. Traditionally, biological psychiatry research has extensively employed animal models and characterizations of rodent behavior. More recently, induced pluripotent stem cells (iPSCs), and induced differentiation of iPSCs into different types of brain cells have offered new alternative strategies to elucidate mechanisms underlying cellular processes. Regardless of how they are created, optimal models should demonstrate face validity, construct validity, and predictive validity to be considered most relevant. This chapter highlights the major animal and cellular models currently used in the research of childhood-onset psychiatric disorders." @default.
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- W4246098983 date "2017-12-01" @default.
- W4246098983 modified "2023-10-14" @default.
- W4246098983 title "Animal and Cellular Models of Pediatric Psychiatric Disorders" @default.
- W4246098983 doi "https://doi.org/10.1093/med/9780190681425.003.0061" @default.
- W4246098983 hasPublicationYear "2017" @default.
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