Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246100188> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4246100188 endingPage "1059" @default.
- W4246100188 startingPage "1050" @default.
- W4246100188 abstract "Mitogen-activated protein kinases (MAPKs) are major components of pathways controlling embryogenesis, cell differentiation, cell proliferation, and cell death. One of the most explored functions of MAPK signaling is the regulation of gene expression by direct or indirect phosphorylation and subsequent activation of transcription factors. In this article, we isolated a novel KRAB-related zinc finger gene named ZNF383 from an early embryo heart cDNA library. The cDNA of ZNF383 is 2220bp, encoding a protein of 475 amino acids. The protein is conserved in evolution across different species. Northern blot analysis indicates that a 2.2kb transcript specific for ZNF383 is detected in most of the examined human adult and embryonic tissues with a higher level in skeletal muscle. In COS-7 cells, ZNF383 protein is localized to nucleus and cytoplasm. ZNF383 is a transcription repressor when fused to Gal-4 DNA-binding domain and cotransfected with VP-16. Deletion analysis indicates that the KRAB box of ZNF383 is responsible for the transcriptional repressor activity. Overexpression of ZNF383 in cells inhibits the transcriptional activities of AP-1 and SRE, suggesting that ZNF383 may act as a negative regulator in MAPK-mediated signaling pathways." @default.
- W4246100188 created "2022-05-12" @default.
- W4246100188 creator A5004047164 @default.
- W4246100188 creator A5012677271 @default.
- W4246100188 creator A5014104166 @default.
- W4246100188 creator A5014149946 @default.
- W4246100188 creator A5025976400 @default.
- W4246100188 creator A5035572340 @default.
- W4246100188 creator A5036016529 @default.
- W4246100188 creator A5046995251 @default.
- W4246100188 creator A5053704104 @default.
- W4246100188 creator A5054859377 @default.
- W4246100188 creator A5090014755 @default.
- W4246100188 creator A5090134632 @default.
- W4246100188 date "2005-08-01" @default.
- W4246100188 modified "2023-10-15" @default.
- W4246100188 title "ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway" @default.
- W4246100188 doi "https://doi.org/10.1016/j.bbrc.2005.05.193" @default.
- W4246100188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15964543" @default.
- W4246100188 hasPublicationYear "2005" @default.
- W4246100188 type Work @default.
- W4246100188 citedByCount "8" @default.
- W4246100188 countsByYear W42461001882013 @default.
- W4246100188 countsByYear W42461001882015 @default.
- W4246100188 countsByYear W42461001882016 @default.
- W4246100188 countsByYear W42461001882018 @default.
- W4246100188 countsByYear W42461001882020 @default.
- W4246100188 crossrefType "journal-article" @default.
- W4246100188 hasAuthorship W4246100188A5004047164 @default.
- W4246100188 hasAuthorship W4246100188A5012677271 @default.
- W4246100188 hasAuthorship W4246100188A5014104166 @default.
- W4246100188 hasAuthorship W4246100188A5014149946 @default.
- W4246100188 hasAuthorship W4246100188A5025976400 @default.
- W4246100188 hasAuthorship W4246100188A5035572340 @default.
- W4246100188 hasAuthorship W4246100188A5036016529 @default.
- W4246100188 hasAuthorship W4246100188A5046995251 @default.
- W4246100188 hasAuthorship W4246100188A5053704104 @default.
- W4246100188 hasAuthorship W4246100188A5054859377 @default.
- W4246100188 hasAuthorship W4246100188A5090014755 @default.
- W4246100188 hasAuthorship W4246100188A5090134632 @default.
- W4246100188 hasConcept C104317684 @default.
- W4246100188 hasConcept C122465829 @default.
- W4246100188 hasConcept C138885662 @default.
- W4246100188 hasConcept C153911025 @default.
- W4246100188 hasConcept C158448853 @default.
- W4246100188 hasConcept C179926584 @default.
- W4246100188 hasConcept C184235292 @default.
- W4246100188 hasConcept C187882448 @default.
- W4246100188 hasConcept C24284526 @default.
- W4246100188 hasConcept C27153228 @default.
- W4246100188 hasConcept C41895202 @default.
- W4246100188 hasConcept C5432534 @default.
- W4246100188 hasConcept C54355233 @default.
- W4246100188 hasConcept C57074206 @default.
- W4246100188 hasConcept C86339819 @default.
- W4246100188 hasConcept C86803240 @default.
- W4246100188 hasConcept C95444343 @default.
- W4246100188 hasConceptScore W4246100188C104317684 @default.
- W4246100188 hasConceptScore W4246100188C122465829 @default.
- W4246100188 hasConceptScore W4246100188C138885662 @default.
- W4246100188 hasConceptScore W4246100188C153911025 @default.
- W4246100188 hasConceptScore W4246100188C158448853 @default.
- W4246100188 hasConceptScore W4246100188C179926584 @default.
- W4246100188 hasConceptScore W4246100188C184235292 @default.
- W4246100188 hasConceptScore W4246100188C187882448 @default.
- W4246100188 hasConceptScore W4246100188C24284526 @default.
- W4246100188 hasConceptScore W4246100188C27153228 @default.
- W4246100188 hasConceptScore W4246100188C41895202 @default.
- W4246100188 hasConceptScore W4246100188C5432534 @default.
- W4246100188 hasConceptScore W4246100188C54355233 @default.
- W4246100188 hasConceptScore W4246100188C57074206 @default.
- W4246100188 hasConceptScore W4246100188C86339819 @default.
- W4246100188 hasConceptScore W4246100188C86803240 @default.
- W4246100188 hasConceptScore W4246100188C95444343 @default.
- W4246100188 hasIssue "4" @default.
- W4246100188 hasLocation W42461001881 @default.
- W4246100188 hasLocation W42461001882 @default.
- W4246100188 hasOpenAccess W4246100188 @default.
- W4246100188 hasPrimaryLocation W42461001881 @default.
- W4246100188 hasRelatedWork W1595182663 @default.
- W4246100188 hasRelatedWork W1964841444 @default.
- W4246100188 hasRelatedWork W1982002493 @default.
- W4246100188 hasRelatedWork W1983916388 @default.
- W4246100188 hasRelatedWork W2000354486 @default.
- W4246100188 hasRelatedWork W2079385745 @default.
- W4246100188 hasRelatedWork W2105022550 @default.
- W4246100188 hasRelatedWork W2139082076 @default.
- W4246100188 hasRelatedWork W3207263689 @default.
- W4246100188 hasRelatedWork W4246100188 @default.
- W4246100188 hasVolume "333" @default.
- W4246100188 isParatext "false" @default.
- W4246100188 isRetracted "false" @default.
- W4246100188 workType "article" @default.