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- W4246121330 abstract "Abstract Combinatorial high throughput methodologies are central for both screening and discovery in synthetic biochemistry and biomedical sciences. They are, however, often reliant on large scale analyses and thus limited by long running time and excessive materials cost. We herein present S ingle PAR ticle C ombinatorial multiplexed L iposome fusion mediated by D NA (SPARCLD), for the parallelized, multi-step and non-deterministic fusion of individual zeptoliter nanocontainers. We observed directly the efficient (>93%), and leakage free stochastic fusion sequences for arrays of surface tethered target liposomes with six freely diffusing populations of cargo liposomes, each functionalized with individual lipidated ssDNA (LiNA) and fluorescent barcoded by distinct ratio of chromophores. The stochastic fusion results in distinct permutation of fusion sequences for each autonomous nanocontainer. Real-time TIRF imaging allowed the direct observation of >16000 fusions and 566 distinct fusion sequences accurately classified using machine learning. The high-density arrays of surface tethered target nanocontainers ∼42,000 containers per mm 2 offers entire combinatorial multiplex screens using only picograms of material." @default.
- W4246121330 created "2022-05-12" @default.
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- W4246121330 date "2021-01-20" @default.
- W4246121330 modified "2023-10-16" @default.
- W4246121330 title "Single particle combinatorial multiplexed liposome fusion mediated by DNA" @default.
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- W4246121330 doi "https://doi.org/10.1101/2021.01.19.427313" @default.
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