Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246133024> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4246133024 abstract "Naphthenic acids (NAs) are carboxylic acids with the formula (CnH2n+ZO2) and are the toxic, persistent constituents of oil sands process-affected waters (OSPW), produced during oil sands extraction. Currently, the proteins and mechanisms involved in NA biodegradation are unknown. Using LC-MS/MS shotgun proteomics, we identified proteins overexpressed during the growth of Pseudomonas fluorescens Pf5 on a model NA (4-n-butylphenyl)-4-butanoic acid (n-BPBA) and commercial NA mixture (Acros). By day 11, >95% of n-BPBA was degraded. With Acros, a 17% reduction in intensity occurred with 10-18 carbon compounds of the Z family -2 to -14 (major NA species in this mixture). A total of 554 proteins (n-BPBA) and 631 proteins (Acros) were overexpressed during growth on NAs; including several transporters (e.g. ABC transporters), suggesting a cellular protective response from NA toxicity. Several proteins associated with fatty acid, lipid and amino acid metabolism were also overexpressed; including acyl-CoA dehydrogenase and acyl-CoA thioesterase II, which catalyze part of the fatty acid beta-oxidation pathway. Indeed, multiple enzymes involved in the fatty acid oxidation pathway were upregulated. Given the presumed structural similarity between alkyl-carboxylic acid side chains and fatty acids, we postulate that P. fluorescens Pf-5 was using existing fatty acid catabolic pathways (among others) during NA degradation." @default.
- W4246133024 created "2022-05-12" @default.
- W4246133024 creator A5008293566 @default.
- W4246133024 creator A5009507869 @default.
- W4246133024 creator A5045757553 @default.
- W4246133024 creator A5056307913 @default.
- W4246133024 creator A5059486514 @default.
- W4246133024 creator A5060944259 @default.
- W4246133024 creator A5064027358 @default.
- W4246133024 creator A5067063439 @default.
- W4246133024 creator A5067337817 @default.
- W4246133024 creator A5071602322 @default.
- W4246133024 creator A5086395134 @default.
- W4246133024 date "2021-04-07" @default.
- W4246133024 modified "2023-09-26" @default.
- W4246133024 title "Differential protein expression during growth on model and commercial mixtures of naphthenic acids in Pseudomonas fluorescens Pf-5" @default.
- W4246133024 doi "https://doi.org/10.22541/au.161781125.54969279/v1" @default.
- W4246133024 hasPublicationYear "2021" @default.
- W4246133024 type Work @default.
- W4246133024 citedByCount "0" @default.
- W4246133024 crossrefType "posted-content" @default.
- W4246133024 hasAuthorship W4246133024A5008293566 @default.
- W4246133024 hasAuthorship W4246133024A5009507869 @default.
- W4246133024 hasAuthorship W4246133024A5045757553 @default.
- W4246133024 hasAuthorship W4246133024A5056307913 @default.
- W4246133024 hasAuthorship W4246133024A5059486514 @default.
- W4246133024 hasAuthorship W4246133024A5060944259 @default.
- W4246133024 hasAuthorship W4246133024A5064027358 @default.
- W4246133024 hasAuthorship W4246133024A5067063439 @default.
- W4246133024 hasAuthorship W4246133024A5067337817 @default.
- W4246133024 hasAuthorship W4246133024A5071602322 @default.
- W4246133024 hasAuthorship W4246133024A5086395134 @default.
- W4246133024 hasBestOaLocation W42461330241 @default.
- W4246133024 hasConcept C181199279 @default.
- W4246133024 hasConcept C185592680 @default.
- W4246133024 hasConcept C192989942 @default.
- W4246133024 hasConcept C2776835041 @default.
- W4246133024 hasConcept C2776991927 @default.
- W4246133024 hasConcept C2779074116 @default.
- W4246133024 hasConcept C515207424 @default.
- W4246133024 hasConcept C523546767 @default.
- W4246133024 hasConcept C543025807 @default.
- W4246133024 hasConcept C54355233 @default.
- W4246133024 hasConcept C55493867 @default.
- W4246133024 hasConcept C62231903 @default.
- W4246133024 hasConcept C86803240 @default.
- W4246133024 hasConcept C96942376 @default.
- W4246133024 hasConceptScore W4246133024C181199279 @default.
- W4246133024 hasConceptScore W4246133024C185592680 @default.
- W4246133024 hasConceptScore W4246133024C192989942 @default.
- W4246133024 hasConceptScore W4246133024C2776835041 @default.
- W4246133024 hasConceptScore W4246133024C2776991927 @default.
- W4246133024 hasConceptScore W4246133024C2779074116 @default.
- W4246133024 hasConceptScore W4246133024C515207424 @default.
- W4246133024 hasConceptScore W4246133024C523546767 @default.
- W4246133024 hasConceptScore W4246133024C543025807 @default.
- W4246133024 hasConceptScore W4246133024C54355233 @default.
- W4246133024 hasConceptScore W4246133024C55493867 @default.
- W4246133024 hasConceptScore W4246133024C62231903 @default.
- W4246133024 hasConceptScore W4246133024C86803240 @default.
- W4246133024 hasConceptScore W4246133024C96942376 @default.
- W4246133024 hasLocation W42461330241 @default.
- W4246133024 hasLocation W42461330242 @default.
- W4246133024 hasOpenAccess W4246133024 @default.
- W4246133024 hasPrimaryLocation W42461330241 @default.
- W4246133024 hasRelatedWork W1927591950 @default.
- W4246133024 hasRelatedWork W1977260638 @default.
- W4246133024 hasRelatedWork W2006699375 @default.
- W4246133024 hasRelatedWork W2082877035 @default.
- W4246133024 hasRelatedWork W2111206898 @default.
- W4246133024 hasRelatedWork W2114155978 @default.
- W4246133024 hasRelatedWork W2497459222 @default.
- W4246133024 hasRelatedWork W3155253090 @default.
- W4246133024 hasRelatedWork W4214949664 @default.
- W4246133024 hasRelatedWork W4246133024 @default.
- W4246133024 isParatext "false" @default.
- W4246133024 isRetracted "false" @default.
- W4246133024 workType "article" @default.