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- W4246133046 abstract "Various polymorphisms of the X-chromosomal monoamine oxidase A (MAO-A) gene were investigated for association with affective disorders. However, none of the studied variants could consistently be associated with either major depressive or bipolar affective disorder. Recently, a positive association between panic disorder and a novel functional repeat polymorphism in the MAO-A gene promoter, with the longer alleles being more active, was reported. Since monoaminergic neurotransmission is supposed to play an important role in affective disorders, we investigated a potential association of this polymorphism with major depressive illness in a sample of 146 unrelated patients of German descent and a control group of 101 individuals with a negative life history for affective disorders. Similarly to the recent findings in panic disorder, we observed a significantly increased frequency of genotypes containing only long alleles in female patients with recurrent major depression in comparison with age- and sex-matched controls. Thus, our data suggest that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for major depressive disorder in females. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801–803, 2000. © 2000 Wiley-Liss, Inc." @default.
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- W4246133046 date "2000-12-04" @default.
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- W4246133046 title "Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder" @default.
- W4246133046 doi "https://doi.org/10.1002/1096-8628(20001204)96:6<801::aid-ajmg21>3.3.co;2-w" @default.
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