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- W4246138514 abstract "Publisher SummaryThis chapter focuses on the Mimiviridae family whose sole member genus is Mimivirus. Mimivirus particles are composed of an icosahedral core protein capsid with a diameter of 0.5 μm, which is uniformly covered with a 0.125 μm thick layer of closely packed fibers. Its central electron-dense nucleocapsid appears to be contained within two 40 Å-thick lipid membranes surrounded by a 70 Å-thick protein shell. The mimivirus particles are highly resistant to extreme conditions or enzymatic treatments such as proteases and glycosidases, which may be due to their distinctive peripheral fiber layer that is thought to be made of a dense mesh of a complex (lipo-) polysaccharide biopolymer akin to the outer coat of bacterial spores. The mimivirus genome is a single linear dsDNA molecule of 1,181,549 bp with an overall nucleotide composition of 72% (A+T). The interior of the particle appears to exhibit two lipid membranes, one encircling a dark core (nucleic acid) and one in direct contact with the interior of the protein capsid. Once the infecting virion is located within a phagocytic vacuole, the particle stargate opens allowing fusion of at least one of the mimivirus lipid membranes with the vacuole membrane. This fusion directly delivers the core of the particle into the host cytoplasm where it serves as a seed to initiate the formation of a virion factory. The two member species of the genus are Acanthamoeba polyphaga mimivirus and Megavirus chilensis." @default.
- W4246138514 created "2022-05-12" @default.
- W4246138514 date "2012-01-01" @default.
- W4246138514 modified "2023-09-27" @default.
- W4246138514 title "Mimiviridae" @default.
- W4246138514 cites W1966870436 @default.
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- W4246138514 doi "https://doi.org/10.1016/b978-0-12-384684-6.00021-5" @default.
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