FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246160841> ?p ?o ?g. }

• W4246160841 endingPage "2845" @default.
• W4246160841 startingPage "2842" @default.
• W4246160841 abstract "Abstract Doxorubicin, a well‐established chemotherapeutic agent, is known to accumulate in the cell nucleus. By using ICP‐MS, we show that the conjugation of two small organometallic rhenium complexes to this structural motif results in a significant redirection of the conjugates from the nucleus to the mitochondria. Despite this relocation, the two bioconjugates display excellent toxicity toward HeLa cells. In addition, we carried out a preliminarily investigation of aspects of cytotoxicity and present evidence that the conjugates disrupt the mitochondrial membrane potential, are strong inhibitors of human Topoisomerase II, and induce apoptosis. Such derivatives may enhance the therapeutic index of the aggressive parent drug and overcome drug resistance by influencing nuclear and mitochondrial homeostasis." @default.
• W4246160841 created "2022-05-12" @default.
• W4246160841 creator A5001975504 @default.
• W4246160841 creator A5046077288 @default.
• W4246160841 creator A5048607332 @default.
• W4246160841 creator A5057788682 @default.
• W4246160841 creator A5059114538 @default.
• W4246160841 creator A5063303431 @default.
• W4246160841 creator A5088869004 @default.
• W4246160841 date "2016-01-22" @default.
• W4246160841 modified "2023-10-14" @default.
• W4246160841 title "Organometallic Rhenium Complexes Divert Doxorubicin to the Mitochondria" @default.
• W4246160841 cites W1517260951 @default.
• W4246160841 cites W1966176339 @default.
• W4246160841 cites W1966579858 @default.
• W4246160841 cites W1971228644 @default.
• W4246160841 cites W1975627657 @default.
• W4246160841 cites W1978454448 @default.
• W4246160841 cites W1994531489 @default.
• W4246160841 cites W2007636056 @default.
• W4246160841 cites W2010183849 @default.
• W4246160841 cites W2010247113 @default.
• W4246160841 cites W2021199155 @default.
• W4246160841 cites W2021913333 @default.
• W4246160841 cites W2022724334 @default.
• W4246160841 cites W2038268619 @default.
• W4246160841 cites W2042698952 @default.
• W4246160841 cites W2051164897 @default.
• W4246160841 cites W2055487497 @default.
• W4246160841 cites W2060279764 @default.
• W4246160841 cites W2060869718 @default.
• W4246160841 cites W2074544404 @default.
• W4246160841 cites W2078053367 @default.
• W4246160841 cites W2083677006 @default.
• W4246160841 cites W2085277655 @default.
• W4246160841 cites W2111426313 @default.
• W4246160841 cites W2128294421 @default.
• W4246160841 cites W2136780657 @default.
• W4246160841 cites W2140330341 @default.
• W4246160841 cites W2160948762 @default.
• W4246160841 cites W2170070762 @default.
• W4246160841 cites W2320324770 @default.
• W4246160841 cites W2406313617 @default.
• W4246160841 cites W4234381551 @default.
• W4246160841 cites W4238598813 @default.
• W4246160841 doi "https://doi.org/10.1002/ange.201511432" @default.
• W4246160841 hasPublicationYear "2016" @default.
• W4246160841 type Work @default.
• W4246160841 citedByCount "24" @default.
• W4246160841 countsByYear W42461608412016 @default.
• W4246160841 countsByYear W42461608412017 @default.
• W4246160841 countsByYear W42461608412018 @default.
• W4246160841 countsByYear W42461608412019 @default.
• W4246160841 countsByYear W42461608412020 @default.
• W4246160841 countsByYear W42461608412021 @default.
• W4246160841 countsByYear W42461608412022 @default.
• W4246160841 countsByYear W42461608412023 @default.
• W4246160841 crossrefType "journal-article" @default.
• W4246160841 hasAuthorship W4246160841A5001975504 @default.
• W4246160841 hasAuthorship W4246160841A5046077288 @default.
• W4246160841 hasAuthorship W4246160841A5048607332 @default.
• W4246160841 hasAuthorship W4246160841A5057788682 @default.
• W4246160841 hasAuthorship W4246160841A5059114538 @default.
• W4246160841 hasAuthorship W4246160841A5063303431 @default.
• W4246160841 hasAuthorship W4246160841A5088869004 @default.
• W4246160841 hasConcept C109316439 @default.
• W4246160841 hasConcept C12554922 @default.
• W4246160841 hasConcept C1491633281 @default.
• W4246160841 hasConcept C178790620 @default.
• W4246160841 hasConcept C185592680 @default.
• W4246160841 hasConcept C190283241 @default.
• W4246160841 hasConcept C202751555 @default.
• W4246160841 hasConcept C2776694085 @default.
• W4246160841 hasConcept C2777366897 @default.
• W4246160841 hasConcept C2780723820 @default.
• W4246160841 hasConcept C2781303535 @default.
• W4246160841 hasConcept C28859421 @default.
• W4246160841 hasConcept C31573885 @default.
• W4246160841 hasConcept C505216180 @default.
• W4246160841 hasConcept C54355233 @default.
• W4246160841 hasConcept C55493867 @default.
• W4246160841 hasConcept C75385678 @default.
• W4246160841 hasConcept C86803240 @default.
• W4246160841 hasConcept C95444343 @default.
• W4246160841 hasConceptScore W4246160841C109316439 @default.
• W4246160841 hasConceptScore W4246160841C12554922 @default.
• W4246160841 hasConceptScore W4246160841C1491633281 @default.
• W4246160841 hasConceptScore W4246160841C178790620 @default.
• W4246160841 hasConceptScore W4246160841C185592680 @default.
• W4246160841 hasConceptScore W4246160841C190283241 @default.
• W4246160841 hasConceptScore W4246160841C202751555 @default.
• W4246160841 hasConceptScore W4246160841C2776694085 @default.
• W4246160841 hasConceptScore W4246160841C2777366897 @default.
• W4246160841 hasConceptScore W4246160841C2780723820 @default.
• W4246160841 hasConceptScore W4246160841C2781303535 @default.
• W4246160841 hasConceptScore W4246160841C28859421 @default.
• W4246160841 hasConceptScore W4246160841C31573885 @default.
• W4246160841 hasConceptScore W4246160841C505216180 @default.

• next