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- W4246176514 abstract "Aminosalicylates were the first medications demonstrated to have efficacy for ulcerative colitis (UC). Most trials of aminosalicylates have been conducted in patients with mild to moderate UC and have demonstrated efficacy in both induction and maintenance of remission. The efficacy of sulfasalazine in the management of UC was first reported in 1942 by Svartz. Subsequent randomized controlled trials (RCTs) demonstrated efficacy of sulfasalazine in the induction of remission in mild to moderate UC. Mesalamine is effective in both induction and maintenance of remission in UC. There are far fewer data supporting the efficacy of aminosalicylates in Crohn's disease (CD). In the National Cooperative CD Study (NCCDS), which randomized patients to sulfasalazine, azathioprine, or prednisone, those randomized to sulfasalazine had superior response compared with placebo at 4 months. Some placebo-controlled trials examined the efficacy of mesalamine formulations in the treatment of mild to moderate CD." @default.
- W4246176514 created "2022-05-12" @default.
- W4246176514 date "2017-03-02" @default.
- W4246176514 modified "2023-09-26" @default.
- W4246176514 title "Aminosalicylates" @default.
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- W4246176514 doi "https://doi.org/10.1002/9781119077633.ch5" @default.
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