Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246199030> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4246199030 endingPage "959" @default.
- W4246199030 startingPage "952" @default.
- W4246199030 abstract "Summary: Purpose: To compare the effectiveness of mono‐therapy clobazam (CLB) to carbamazepine (CBZ) and phenytoin (PHT) in children with epilepsy. Methods: Children aged 2–16 years with newly diagnosed epilepsy or previous failure of one drug (for poor efficacy or side effects) were assigned to one of two study arms and then randomized–CLB versus CBZ or CLB versus PHT. Eligible children had partial epilepsies or only generalized tonic‐clonic seizures. After a drug initiation protocol, monotherapy treatment mimicked the usual routines used by Canadian child neurologists. Blinding used a “double dummy” technique with blinded medication serum levels (6–point scale). Intention to treat analysis using survival curves assessed the primary end‐point–length of retention on the initial medication during the year after randomization. Results: Fifteen centers entered 235 patients: 159 randomized to CLB versus CBZ and 76 to CLB versus PHT. Altogether, in all study arms, 119 received CLB, 78 CBZ, and 38 PHT. Overall, 56% continued to receive the original medication for l year with no difference between CLB and standard therapy (CBZ and PHT). Seizure control was equivalent for all three medications, as were side effects. PHT and CBZ induced more biologic side effects, such as rash, while CLB induced slightly more behavioral effects. Tolerance developed in 7.5% of patients receiving CLB, 4.2% with CBZ and 6.7% with PHT. Conclusions: CLB should be considered as “first line” monotherapy along with CBZ and PHT for all partial and selected generalized childhood epilepsies." @default.
- W4246199030 created "2022-05-12" @default.
- W4246199030 date "1998-09-01" @default.
- W4246199030 modified "2023-10-16" @default.
- W4246199030 title "Clobazam Has Equivalent Efficacy to Carbamazepine and Phenytoin as Monotherapy for Childhood Epilepsy" @default.
- W4246199030 cites W1965450907 @default.
- W4246199030 cites W1968244610 @default.
- W4246199030 cites W1992056152 @default.
- W4246199030 cites W2014521622 @default.
- W4246199030 cites W2039674635 @default.
- W4246199030 cites W2045274557 @default.
- W4246199030 cites W2063199611 @default.
- W4246199030 cites W2114002180 @default.
- W4246199030 cites W2320058521 @default.
- W4246199030 cites W2322086287 @default.
- W4246199030 cites W2419842409 @default.
- W4246199030 cites W4234096001 @default.
- W4246199030 cites W4239594659 @default.
- W4246199030 doi "https://doi.org/10.1111/j.1528-1157.1998.tb01444.x" @default.
- W4246199030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9738674" @default.
- W4246199030 hasPublicationYear "1998" @default.
- W4246199030 type Work @default.
- W4246199030 citedByCount "80" @default.
- W4246199030 countsByYear W42461990302012 @default.
- W4246199030 countsByYear W42461990302013 @default.
- W4246199030 countsByYear W42461990302014 @default.
- W4246199030 countsByYear W42461990302015 @default.
- W4246199030 countsByYear W42461990302016 @default.
- W4246199030 countsByYear W42461990302017 @default.
- W4246199030 countsByYear W42461990302018 @default.
- W4246199030 countsByYear W42461990302019 @default.
- W4246199030 countsByYear W42461990302020 @default.
- W4246199030 countsByYear W42461990302021 @default.
- W4246199030 countsByYear W42461990302022 @default.
- W4246199030 countsByYear W42461990302023 @default.
- W4246199030 crossrefType "journal-article" @default.
- W4246199030 hasBestOaLocation W42461990301 @default.
- W4246199030 hasConcept C118552586 @default.
- W4246199030 hasConcept C126322002 @default.
- W4246199030 hasConcept C168563851 @default.
- W4246199030 hasConcept C187212893 @default.
- W4246199030 hasConcept C203092338 @default.
- W4246199030 hasConcept C204243189 @default.
- W4246199030 hasConcept C2775858608 @default.
- W4246199030 hasConcept C2777907850 @default.
- W4246199030 hasConcept C2778186239 @default.
- W4246199030 hasConcept C2778337148 @default.
- W4246199030 hasConcept C2778570526 @default.
- W4246199030 hasConcept C2779253243 @default.
- W4246199030 hasConcept C2779979230 @default.
- W4246199030 hasConcept C42219234 @default.
- W4246199030 hasConcept C71924100 @default.
- W4246199030 hasConcept C98274493 @default.
- W4246199030 hasConceptScore W4246199030C118552586 @default.
- W4246199030 hasConceptScore W4246199030C126322002 @default.
- W4246199030 hasConceptScore W4246199030C168563851 @default.
- W4246199030 hasConceptScore W4246199030C187212893 @default.
- W4246199030 hasConceptScore W4246199030C203092338 @default.
- W4246199030 hasConceptScore W4246199030C204243189 @default.
- W4246199030 hasConceptScore W4246199030C2775858608 @default.
- W4246199030 hasConceptScore W4246199030C2777907850 @default.
- W4246199030 hasConceptScore W4246199030C2778186239 @default.
- W4246199030 hasConceptScore W4246199030C2778337148 @default.
- W4246199030 hasConceptScore W4246199030C2778570526 @default.
- W4246199030 hasConceptScore W4246199030C2779253243 @default.
- W4246199030 hasConceptScore W4246199030C2779979230 @default.
- W4246199030 hasConceptScore W4246199030C42219234 @default.
- W4246199030 hasConceptScore W4246199030C71924100 @default.
- W4246199030 hasConceptScore W4246199030C98274493 @default.
- W4246199030 hasIssue "9" @default.
- W4246199030 hasLocation W42461990301 @default.
- W4246199030 hasLocation W42461990302 @default.
- W4246199030 hasOpenAccess W4246199030 @default.
- W4246199030 hasPrimaryLocation W42461990301 @default.
- W4246199030 hasRelatedWork W134009642 @default.
- W4246199030 hasRelatedWork W146116879 @default.
- W4246199030 hasRelatedWork W1985063797 @default.
- W4246199030 hasRelatedWork W2003087813 @default.
- W4246199030 hasRelatedWork W2011853562 @default.
- W4246199030 hasRelatedWork W2089362184 @default.
- W4246199030 hasRelatedWork W2260632073 @default.
- W4246199030 hasRelatedWork W2460303885 @default.
- W4246199030 hasRelatedWork W2527238830 @default.
- W4246199030 hasRelatedWork W2960034844 @default.
- W4246199030 hasVolume "39" @default.
- W4246199030 isParatext "false" @default.
- W4246199030 isRetracted "false" @default.
- W4246199030 workType "article" @default.