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• W4246219673 abstract "<sec> <title>BACKGROUND</title> Internet-based cognitive behavior therapy (I-CBT) for adolescents with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has been shown to be effective in a randomized controlled trial (RCT; Fatigue in Teenagers on the Internet [FITNET]). FITNET can cause a significant reduction in fatigue and disability. </sec> <sec> <title>OBJECTIVE</title> We aimed to investigate whether FITNET treatment implemented in routine clinical care (IMP-FITNET) was as effective, using the outcomes of the FITNET RCT as the benchmark. </sec> <sec> <title>METHODS</title> Outcomes of CFS/ME adolescents who started IMP-FITNET between October 2012 and March 2018 as part of routine clinical care were compared to the outcomes in the FITNET RCT. The primary outcome was fatigue severity assessed posttreatment. The secondary outcomes were self-reported physical functioning, school attendance, and recovery rates. Clinically relevant deterioration was assessed posttreatment, and for this outcome, a face-to-face CBT trial was used as the benchmark. The attitude of therapists toward the usability of IMP-FITNET was assessed through semistructured interviews. The number of face-to-face consultations during IMP-FITNET was registered. </sec> <sec> <title>RESULTS</title> Of the 384 referred adolescents with CFS/ME, 244 (63.5%) started IMP-FITNET, 84 (21.9%) started face-to-face CBT, and 56 (14.6%) were not eligible for CBT. Posttreatment scores for fatigue severity (mean 26.0, SD 13.8), physical functioning (mean 88.2, SD 15.0), and full school attendance (mean 84.3, SD 26.5) fell within the 95% CIs of the FITNET RCT. Deterioration of fatigue and physical functioning after IMP-FITNET was observed at rates of 1.2% (n=3) and 4.1% (n=10), respectively, which is comparable to a waiting list condition (fatigue: 1.2% vs 5.7%, χ²₁=3.5, <i>P</i>=.06; physical functioning: 4.1% vs 11.4%, χ²₁=3.3, <i>P</i>=.07). Moreover, 41 (16.8%) IMP-FITNET patients made use of face-to-face consultations. </sec> <sec> <title>CONCLUSIONS</title> IMP-FITNET is an effective and safe treatment for adolescents with CFS/ME in routine clinical care. </sec>" @default.
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• W4246219673 date "2020-10-08" @default.
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• W4246219673 title "Effectiveness of Internet-Based Cognitive Behavior Therapy (Fatigue in Teenagers on the Internet) for Adolescents With Chronic Fatigue Syndrome in Routine Clinical Care: Observational Study (Preprint)" @default.
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• W4246219673 doi "https://doi.org/10.2196/preprints.24839" @default.
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