Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246232275> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4246232275 endingPage "19" @default.
- W4246232275 startingPage "15" @default.
- W4246232275 abstract "In order to demonstrate the relationship between microsatellite instability and other types of genomic instability, a series of 56 sporadic colorectal carcinomas was investigated by flow cytometrical ploidy analysis, oligonucleotide fingerprinting, and microsatellite polymerase chain reaction (PCR). Stabilization of the p53 gene product was analysed by immunohistochemistry and proliferative activity was determined flow cytometrically and by silver staining of nucleolar organizer regions (AgNORs). Of the 56 carcinomas, 11 (19 per cent) exhibited microsatellite instability; 33 of the cases were aneuploid (59 per cent) and 29 (52 per cent) showed alterations of the oligonucleotide fingerprints. There was a significant correlation of microsatellite instability with localization of these tumours proximal to the splenic flexure, diploid DNA content, and less frequent p53 stabilization. A solid growth pattern, mucinous differentiation, and a Crohn's-like lymphoid infiltrate were also characteristic for those tumours. The results demonstrate for the first time a significantly lower proliferative activity in tumours with microsatellite instability. Data obtained from DNA flow cytometry or from oligonucleotide fingerprinting did not correlate with such tumour characteristics. It is proposed that the use of microsatellite PCR facilitates specifically the detection of a group of colorectal cancers which may differ in pathogenesis and perhaps prognosis." @default.
- W4246232275 created "2022-05-12" @default.
- W4246232275 creator A5005781809 @default.
- W4246232275 creator A5007928838 @default.
- W4246232275 creator A5024681233 @default.
- W4246232275 creator A5028984477 @default.
- W4246232275 creator A5035577287 @default.
- W4246232275 creator A5042322752 @default.
- W4246232275 creator A5059725882 @default.
- W4246232275 date "1996-05-01" @default.
- W4246232275 modified "2023-10-14" @default.
- W4246232275 title "GENOMIC INSTABILITY IN COLORECTAL CARCINOMAS: COMPARISON OF DIFFERENT EVALUATION METHODS AND THEIR BIOLOGICAL SIGNIFICANCE" @default.
- W4246232275 doi "https://doi.org/10.1002/(sici)1096-9896(199605)179:1<15::aid-path553>3.3.co;2-e" @default.
- W4246232275 hasPublicationYear "1996" @default.
- W4246232275 type Work @default.
- W4246232275 citedByCount "1" @default.
- W4246232275 crossrefType "journal-article" @default.
- W4246232275 hasAuthorship W4246232275A5005781809 @default.
- W4246232275 hasAuthorship W4246232275A5007928838 @default.
- W4246232275 hasAuthorship W4246232275A5024681233 @default.
- W4246232275 hasAuthorship W4246232275A5028984477 @default.
- W4246232275 hasAuthorship W4246232275A5035577287 @default.
- W4246232275 hasAuthorship W4246232275A5042322752 @default.
- W4246232275 hasAuthorship W4246232275A5059725882 @default.
- W4246232275 hasConcept C104317684 @default.
- W4246232275 hasConcept C111824103 @default.
- W4246232275 hasConcept C121608353 @default.
- W4246232275 hasConcept C129312508 @default.
- W4246232275 hasConcept C142724271 @default.
- W4246232275 hasConcept C143191323 @default.
- W4246232275 hasConcept C143425029 @default.
- W4246232275 hasConcept C153911025 @default.
- W4246232275 hasConcept C17757408 @default.
- W4246232275 hasConcept C178169997 @default.
- W4246232275 hasConcept C180754005 @default.
- W4246232275 hasConcept C203014093 @default.
- W4246232275 hasConcept C204232928 @default.
- W4246232275 hasConcept C2779767149 @default.
- W4246232275 hasConcept C49105822 @default.
- W4246232275 hasConcept C502942594 @default.
- W4246232275 hasConcept C526805850 @default.
- W4246232275 hasConcept C54355233 @default.
- W4246232275 hasConcept C552990157 @default.
- W4246232275 hasConcept C553184892 @default.
- W4246232275 hasConcept C61320498 @default.
- W4246232275 hasConcept C71924100 @default.
- W4246232275 hasConcept C86803240 @default.
- W4246232275 hasConceptScore W4246232275C104317684 @default.
- W4246232275 hasConceptScore W4246232275C111824103 @default.
- W4246232275 hasConceptScore W4246232275C121608353 @default.
- W4246232275 hasConceptScore W4246232275C129312508 @default.
- W4246232275 hasConceptScore W4246232275C142724271 @default.
- W4246232275 hasConceptScore W4246232275C143191323 @default.
- W4246232275 hasConceptScore W4246232275C143425029 @default.
- W4246232275 hasConceptScore W4246232275C153911025 @default.
- W4246232275 hasConceptScore W4246232275C17757408 @default.
- W4246232275 hasConceptScore W4246232275C178169997 @default.
- W4246232275 hasConceptScore W4246232275C180754005 @default.
- W4246232275 hasConceptScore W4246232275C203014093 @default.
- W4246232275 hasConceptScore W4246232275C204232928 @default.
- W4246232275 hasConceptScore W4246232275C2779767149 @default.
- W4246232275 hasConceptScore W4246232275C49105822 @default.
- W4246232275 hasConceptScore W4246232275C502942594 @default.
- W4246232275 hasConceptScore W4246232275C526805850 @default.
- W4246232275 hasConceptScore W4246232275C54355233 @default.
- W4246232275 hasConceptScore W4246232275C552990157 @default.
- W4246232275 hasConceptScore W4246232275C553184892 @default.
- W4246232275 hasConceptScore W4246232275C61320498 @default.
- W4246232275 hasConceptScore W4246232275C71924100 @default.
- W4246232275 hasConceptScore W4246232275C86803240 @default.
- W4246232275 hasIssue "1" @default.
- W4246232275 hasLocation W42462322751 @default.
- W4246232275 hasOpenAccess W4246232275 @default.
- W4246232275 hasPrimaryLocation W42462322751 @default.
- W4246232275 hasRelatedWork W1788575481 @default.
- W4246232275 hasRelatedWork W1963927131 @default.
- W4246232275 hasRelatedWork W1987052232 @default.
- W4246232275 hasRelatedWork W2002928675 @default.
- W4246232275 hasRelatedWork W2058511382 @default.
- W4246232275 hasRelatedWork W2117689389 @default.
- W4246232275 hasRelatedWork W2350179104 @default.
- W4246232275 hasRelatedWork W2480411 @default.
- W4246232275 hasRelatedWork W4246232275 @default.
- W4246232275 hasRelatedWork W4250325211 @default.
- W4246232275 hasVolume "179" @default.
- W4246232275 isParatext "false" @default.
- W4246232275 isRetracted "false" @default.
- W4246232275 workType "article" @default.