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• W4246296469 abstract "Abstract PurposeDynamic 60-minute positron-emission-tomography (PET) imaging with the novel tau radiotracer [ 18 F]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for [ 18 F]PI-2620 tau-PET imaging of PSP. MethodsThirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [ 18 F]PI-2620 PET was performed by a dynamic 60 minute scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0-60, 0-50, 0-40, 0-30, and 0-20 minutes p.i.). Standardized uptake value ratios (SUVrs) were obtained 20-40, 30-50, and 40-60 minutes p.i.. All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP-RS from HCs in predefined subcortical and cortical target regions (effect size, area under the curve (AUC), multi-region classifier).Results0-50 and 0-40 DVR showed equivalent effect sizes as 0-60 DVR (averaged Cohen’s d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0-30 or 0-20 DVR. The 20-40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen’s d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0-60 DVR (AUC: 0.96), 0-40 DVR (AUC: 0.96), and 20-40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86%.ConclusionTruncated and static imaging windows can be used for [ 18 F]PI-2620 PET imaging of PSP. 0-40 minute dynamic scanning offers the best balance between accuracy and economic scanning." @default.
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• W4246296469 date "2021-02-09" @default.
• W4246296469 modified "2023-10-15" @default.
• W4246296469 title "Feasibility of Short Imaging Protocols for [18F]PI-2620 Tau-PET in Progressive Supranuclear Palsy" @default.
• W4246296469 doi "https://doi.org/10.21203/rs.3.rs-180630/v1" @default.
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