FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246330944> ?p ?o ?g. }

• W4246330944 abstract "Background Neonatal sepsis and necrotizing enterocolitis (NEC) cause significant neonatal mortality and morbidity in spite of appropriate antibiotic therapy. Enhancing host defence and modulating inflammation by using lactoferrin as an adjunct to antibiotics in the treatment of sepsis and/or NEC may improve clinical outcomes. Objectives The primary objective is to assess safety and efficacy of oral lactoferrin as an adjunct to antibiotics in the treatment of neonates with suspected or confirmed sepsis and/or NEC. Search methods Relevant trials in any language were searched in July 2011 in the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), MEDLINE, PREMEDLINE, EMBASE, CINAHL, web sites: www.clinicaltrials.gov and www.controlled‐trials.com, abstracts from the annual meeting of Pediatric Academic Societies (1990 to July 2011), by contacting authors who have published in this field, from the reference lists of identified clinical trials and in the reviewer's personal files. Selection criteria Randomized or quasi‐randomized controlled trials evaluating oral lactoferrin (at any dose or duration) used as an adjunct to antibiotic therapy compared with antibiotic therapy alone (with or without placebo) or other adjuncts to antibiotic therapy to treat neonates at any gestational age up to 44 weeks postmenstrual age with confirmed or suspected sepsis or necrotizing enterocolitis (Bell's Stage II or III). Data collection and analysis We used the standardized methods of the Cochrane Neonatal Review Group (CNRG) for conducting a systematic review and for assessing the methodological quality of the studies (http://neonatal.cochrane.org/en/index.html). The titles and the abstracts of studies identified by the search strategy were independently assessed by the two review authors and full text version was obtained for assessment if necessary. Forms were designed for trial inclusion/exclusion and data extraction. Main results We did not identify any eligible neonatal trial evaluating lactoferrin for treatment of neonatal sepsis or NEC. Authors' conclusions Implications for practice: Currently there is no evidence to recommend or refute the use of lactoferrin for the treatment of neonatal sepsis or necrotizing enterocolitis as an adjunct to antibiotic therapy. Implications for research: The safety and efficacy of different preparations and doses of lactoferrin need to be established in neonates. Well designed adequately powered randomized multicenter trials are needed to address the efficacy and safety of lactoferrin in the treatment of neonatal sepsis and necrotizing enterocolitis. These trials should evaluate long‐term neurodevelopmental and pulmonary outcomes in addition to short‐term outcomes." @default.
• W4246330944 created "2022-05-12" @default.
• W4246330944 creator A5027937113 @default.
• W4246330944 creator A5056894749 @default.
• W4246330944 date "2011-10-05" @default.
• W4246330944 modified "2023-09-28" @default.
• W4246330944 title "Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates" @default.
• W4246330944 cites W126342968 @default.
• W4246330944 cites W1600138259 @default.
• W4246330944 cites W16631805 @default.
• W4246330944 cites W1778186888 @default.
• W4246330944 cites W1972941081 @default.
• W4246330944 cites W1979500720 @default.
• W4246330944 cites W1979855883 @default.
• W4246330944 cites W1997947168 @default.
• W4246330944 cites W2012017557 @default.
• W4246330944 cites W2015885078 @default.
• W4246330944 cites W2017046795 @default.
• W4246330944 cites W2019549525 @default.
• W4246330944 cites W2031375858 @default.
• W4246330944 cites W2037624452 @default.
• W4246330944 cites W2042100571 @default.
• W4246330944 cites W2043723908 @default.
• W4246330944 cites W2057682417 @default.
• W4246330944 cites W2064723143 @default.
• W4246330944 cites W2069711840 @default.
• W4246330944 cites W2071589683 @default.
• W4246330944 cites W2122232621 @default.
• W4246330944 cites W2123559285 @default.
• W4246330944 cites W2143426164 @default.
• W4246330944 cites W2155248348 @default.
• W4246330944 cites W2159006400 @default.
• W4246330944 cites W2165467737 @default.
• W4246330944 cites W2168581177 @default.
• W4246330944 cites W4210999361 @default.
• W4246330944 doi "https://doi.org/10.1002/14651858.cd007138.pub3" @default.
• W4246330944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21975766" @default.
• W4246330944 hasPublicationYear "2011" @default.
• W4246330944 type Work @default.
• W4246330944 citedByCount "7" @default.
• W4246330944 countsByYear W42463309442015 @default.
• W4246330944 countsByYear W42463309442016 @default.
• W4246330944 countsByYear W42463309442018 @default.
• W4246330944 countsByYear W42463309442019 @default.
• W4246330944 countsByYear W42463309442020 @default.
• W4246330944 countsByYear W42463309442022 @default.
• W4246330944 crossrefType "journal-article" @default.
• W4246330944 hasAuthorship W4246330944A5027937113 @default.
• W4246330944 hasAuthorship W4246330944A5056894749 @default.
• W4246330944 hasConcept C126322002 @default.
• W4246330944 hasConcept C142724271 @default.
• W4246330944 hasConcept C168563851 @default.
• W4246330944 hasConcept C177713679 @default.
• W4246330944 hasConcept C187212893 @default.
• W4246330944 hasConcept C204787440 @default.
• W4246330944 hasConcept C27081682 @default.
• W4246330944 hasConcept C2775953899 @default.
• W4246330944 hasConcept C2776478404 @default.
• W4246330944 hasConcept C2778384902 @default.
• W4246330944 hasConcept C2779303187 @default.
• W4246330944 hasConcept C71924100 @default.
• W4246330944 hasConceptScore W4246330944C126322002 @default.
• W4246330944 hasConceptScore W4246330944C142724271 @default.
• W4246330944 hasConceptScore W4246330944C168563851 @default.
• W4246330944 hasConceptScore W4246330944C177713679 @default.
• W4246330944 hasConceptScore W4246330944C187212893 @default.
• W4246330944 hasConceptScore W4246330944C204787440 @default.
• W4246330944 hasConceptScore W4246330944C27081682 @default.
• W4246330944 hasConceptScore W4246330944C2775953899 @default.
• W4246330944 hasConceptScore W4246330944C2776478404 @default.
• W4246330944 hasConceptScore W4246330944C2778384902 @default.
• W4246330944 hasConceptScore W4246330944C2779303187 @default.
• W4246330944 hasConceptScore W4246330944C71924100 @default.
• W4246330944 hasLocation W42463309441 @default.
• W4246330944 hasLocation W42463309442 @default.
• W4246330944 hasOpenAccess W4246330944 @default.
• W4246330944 hasPrimaryLocation W42463309441 @default.
• W4246330944 hasRelatedWork W2003759542 @default.
• W4246330944 hasRelatedWork W2011189958 @default.
• W4246330944 hasRelatedWork W2046860342 @default.
• W4246330944 hasRelatedWork W2117129893 @default.
• W4246330944 hasRelatedWork W2163291203 @default.
• W4246330944 hasRelatedWork W2331916472 @default.
• W4246330944 hasRelatedWork W2800533041 @default.
• W4246330944 hasRelatedWork W3209608762 @default.
• W4246330944 hasRelatedWork W4205506599 @default.
• W4246330944 hasRelatedWork W4220918652 @default.
• W4246330944 isParatext "false" @default.
• W4246330944 isRetracted "false" @default.
• W4246330944 workType "article" @default.