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- W4246343399 abstract "This chapter describes various aspects of primary platelet disorders. Platelets are small biconcave cells that are essential for adequate hemostasis. Platelet disorders can lead to both hemorrhagic and ischemic strokes. Platelet abnormalities can be divided into quantitative abnormalities or qualitative abnormalities of platelet function. Primary thrombocythemia is a rare myeloproliferative disorder in which platelets are produced in excess. The diagnosis of primary thrombocythemia requires exclusion of other causes of increased platelets such as carcinoma and infection. Treatment of primary thrombocythemia can include plateletpheresis and chemotherapy. Cessation of smoking may also lessen the frequency of thrombotic events. Idiopathic thrombocytopenic purpura is an autoimmune disorder in which IgM and IgG antibodies attack the platelet glycoprotein membrane, diminishing the lifespan of the platelet. Platelet dysfunction is seen in nearly all patients undergoing cardiopulmonary bypass (CPB). Most of these abnormalities of platelet aggregation and activation are reversible soon after cessation of CPB. Hemorrhagic complications are often due to additional variables affecting hemostasis during surgery such as the use of heparin. The treatment of bleeding complications may include platelet transfusion and desmopressin." @default.
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- W4246343399 date "1997-01-01" @default.
- W4246343399 modified "2023-09-28" @default.
- W4246343399 title "Primary Platelet Disorders" @default.
- W4246343399 doi "https://doi.org/10.1016/b978-012743170-3/50111-4" @default.
- W4246343399 hasPublicationYear "1997" @default.
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