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• W4246382075 abstract "Based on the previously reported lead compound, a series of benzofuran derivatives were prepared to study their antagonistic activities to A2A receptor. The replacement of the phenyl group at the 4-position with a heterocyclic ring improved the PK profile and aqueous solubility. From these studies, we discovered a potent new A2A antagonist, 12a, which has both a good oral bioavailability and in vivo efficacy on motor disability in MPTP-treated common marmosets." @default.
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• W4246382075 date "2010-06-01" @default.
• W4246382075 modified "2023-10-01" @default.
• W4246382075 title "Synthetic studies on selective adenosine A2A receptor antagonists. Part II: Synthesis and structure–activity relationships of novel benzofuran derivatives" @default.
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• W4246382075 doi "https://doi.org/10.1016/j.bmcl.2010.04.058" @default.
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