Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246395963> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4246395963 abstract "Glycolysis inhibition remains aspirational in cancer therapy. We recently described a promising phosphonate inhibitor of Enolase for cancers harboring deletions in ENO1. Here, we describe the application of nitroheterocycle pro-drugs capitalizing on tumor hypoxia. These bioreducible pro-drugs exhibit up to 14-fold greater potency under hypoxic conditions compared to normoxia and exhibit robust stability in biological fluids. Our work provides strong proof-of-concept for using bioreduction as a pro-drug delivery strategy in the context of Enolase inhibition." @default.
- W4246395963 created "2022-05-12" @default.
- W4246395963 creator A5023686259 @default.
- W4246395963 creator A5023947936 @default.
- W4246395963 creator A5024047574 @default.
- W4246395963 creator A5040925017 @default.
- W4246395963 creator A5055700997 @default.
- W4246395963 creator A5091138132 @default.
- W4246395963 date "2020-03-26" @default.
- W4246395963 modified "2023-09-25" @default.
- W4246395963 title "Bioreducible Pro-drug Inhibitors of Enolase" @default.
- W4246395963 doi "https://doi.org/10.26434/chemrxiv.12033303" @default.
- W4246395963 hasPublicationYear "2020" @default.
- W4246395963 type Work @default.
- W4246395963 citedByCount "0" @default.
- W4246395963 crossrefType "posted-content" @default.
- W4246395963 hasAuthorship W4246395963A5023686259 @default.
- W4246395963 hasAuthorship W4246395963A5023947936 @default.
- W4246395963 hasAuthorship W4246395963A5024047574 @default.
- W4246395963 hasAuthorship W4246395963A5040925017 @default.
- W4246395963 hasAuthorship W4246395963A5055700997 @default.
- W4246395963 hasAuthorship W4246395963A5091138132 @default.
- W4246395963 hasBestOaLocation W42463959631 @default.
- W4246395963 hasConcept C121608353 @default.
- W4246395963 hasConcept C151730666 @default.
- W4246395963 hasConcept C178790620 @default.
- W4246395963 hasConcept C185592680 @default.
- W4246395963 hasConcept C188618488 @default.
- W4246395963 hasConcept C203014093 @default.
- W4246395963 hasConcept C204232928 @default.
- W4246395963 hasConcept C2777626080 @default.
- W4246395963 hasConcept C2779343474 @default.
- W4246395963 hasConcept C2780035454 @default.
- W4246395963 hasConcept C2983331546 @default.
- W4246395963 hasConcept C502942594 @default.
- W4246395963 hasConcept C540031477 @default.
- W4246395963 hasConcept C54355233 @default.
- W4246395963 hasConcept C55493867 @default.
- W4246395963 hasConcept C70721500 @default.
- W4246395963 hasConcept C7836513 @default.
- W4246395963 hasConcept C86803240 @default.
- W4246395963 hasConcept C98274493 @default.
- W4246395963 hasConceptScore W4246395963C121608353 @default.
- W4246395963 hasConceptScore W4246395963C151730666 @default.
- W4246395963 hasConceptScore W4246395963C178790620 @default.
- W4246395963 hasConceptScore W4246395963C185592680 @default.
- W4246395963 hasConceptScore W4246395963C188618488 @default.
- W4246395963 hasConceptScore W4246395963C203014093 @default.
- W4246395963 hasConceptScore W4246395963C204232928 @default.
- W4246395963 hasConceptScore W4246395963C2777626080 @default.
- W4246395963 hasConceptScore W4246395963C2779343474 @default.
- W4246395963 hasConceptScore W4246395963C2780035454 @default.
- W4246395963 hasConceptScore W4246395963C2983331546 @default.
- W4246395963 hasConceptScore W4246395963C502942594 @default.
- W4246395963 hasConceptScore W4246395963C540031477 @default.
- W4246395963 hasConceptScore W4246395963C54355233 @default.
- W4246395963 hasConceptScore W4246395963C55493867 @default.
- W4246395963 hasConceptScore W4246395963C70721500 @default.
- W4246395963 hasConceptScore W4246395963C7836513 @default.
- W4246395963 hasConceptScore W4246395963C86803240 @default.
- W4246395963 hasConceptScore W4246395963C98274493 @default.
- W4246395963 hasLocation W42463959631 @default.
- W4246395963 hasOpenAccess W4246395963 @default.
- W4246395963 hasPrimaryLocation W42463959631 @default.
- W4246395963 hasRelatedWork W2000311410 @default.
- W4246395963 hasRelatedWork W2026531830 @default.
- W4246395963 hasRelatedWork W2299120098 @default.
- W4246395963 hasRelatedWork W2330096593 @default.
- W4246395963 hasRelatedWork W2399596785 @default.
- W4246395963 hasRelatedWork W2789704176 @default.
- W4246395963 hasRelatedWork W2949153590 @default.
- W4246395963 hasRelatedWork W2951494344 @default.
- W4246395963 hasRelatedWork W3121632856 @default.
- W4246395963 hasRelatedWork W4292202196 @default.
- W4246395963 isParatext "false" @default.
- W4246395963 isRetracted "false" @default.
- W4246395963 workType "article" @default.