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- W4246402337 abstract "The anti-inflammatory action of annexin I, a secreted calcium- and phospholipid-binding protein, includes inhibiting neutrophil transmigration from the blood into tissue. Walther et al. report that annexin I acts through the formyl peptide receptor (FPR) on human neutrophils. In contrast, bacterial formyl peptides, the classical FPR ligands, are proinflammatory. When bound to the receptor, annexin I-derived peptides and formyl peptides elicit a similar elevation in intracellular calcium in a G-protein-dependent manner. Competition assays indicate that the two peptides likely bind to different regions of FPR. The authors propose that the two different ligands activate different receptor-initiated signaling cascades that result in opposing inflammatory responses.Walther, A., Riehemann, K., and Gerke, V. (2000) A novel ligand of the formyl peptide receptor: Annexin I regulates neutrophil extravasation by interacting with the FPR. Mol. Cell 5: 831-840. [Online Journal]" @default.
- W4246402337 created "2022-05-12" @default.
- W4246402337 date "2000-05-23" @default.
- W4246402337 modified "2023-09-25" @default.
- W4246402337 title "Same Receptor, Different Effects" @default.
- W4246402337 doi "https://doi.org/10.1126/scisignal.332000tw7" @default.
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