Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246418337> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4246418337 endingPage "4926" @default.
- W4246418337 startingPage "4918" @default.
- W4246418337 abstract "Yeast GCN4 and the Jun oncoprotein are transcriptional activators that bind DNA via a bZIP domain consisting of a leucine zipper dimerization element and an adjacent basic region that directly contacts DNA. Two highly conserved alanines (Ala-238 and Ala-239 in GCN4) and an invariant asparagine (Asn-235) in the basic region have been proposed to play important roles in DNA sequence recognition by bZIP proteins. Surprisingly, these conserved residues can be functionally replaced in GCN4 and in a derivative containing the Jun basic region (Jun-GCN4). The ability of an amino acid to functionally substitute for Asn-235 does not correlate with its preference for assuming the N-cap position of an alpha helix. This finding argues against the proposal of the scissors grip model that the invariant asparagine forms an N cap that permits the basic region to bend sharply and wrap around the DNA. In contrast to a prediction of the induced fork model, the pattern of functional substitutions of the conserved alanines together with the results of uracil interference experiments suggests that Ala-238 and Ala-239 do not make base-specific DNA contacts. Finally, the Jun-GCN4 chimeric proteins appear much more active in vivo than expected from their DNA-binding properties in vitro. The mechanistic and evolutionary implications of these results are discussed." @default.
- W4246418337 created "2022-05-12" @default.
- W4246418337 creator A5076662333 @default.
- W4246418337 creator A5083029357 @default.
- W4246418337 date "1991-10-01" @default.
- W4246418337 modified "2023-09-27" @default.
- W4246418337 title "Highly Conserved Residues in the bZIP Domain of Yeast GCN4 Are Not Essential for DNA Binding" @default.
- W4246418337 cites W117652395 @default.
- W4246418337 cites W1595546948 @default.
- W4246418337 cites W1922068407 @default.
- W4246418337 cites W1974081085 @default.
- W4246418337 cites W1975511017 @default.
- W4246418337 cites W1981601576 @default.
- W4246418337 cites W1995921536 @default.
- W4246418337 cites W1997174711 @default.
- W4246418337 cites W1999602995 @default.
- W4246418337 cites W2008570049 @default.
- W4246418337 cites W2011409082 @default.
- W4246418337 cites W2012318656 @default.
- W4246418337 cites W2016736163 @default.
- W4246418337 cites W2018507982 @default.
- W4246418337 cites W2026598193 @default.
- W4246418337 cites W2028644963 @default.
- W4246418337 cites W2038352589 @default.
- W4246418337 cites W2045412127 @default.
- W4246418337 cites W2055257235 @default.
- W4246418337 cites W2058215940 @default.
- W4246418337 cites W2060690425 @default.
- W4246418337 cites W2073548049 @default.
- W4246418337 cites W2078952292 @default.
- W4246418337 cites W2081062649 @default.
- W4246418337 cites W2081359387 @default.
- W4246418337 cites W2087085187 @default.
- W4246418337 cites W2087640316 @default.
- W4246418337 cites W2093217670 @default.
- W4246418337 cites W2110374270 @default.
- W4246418337 cites W2159390753 @default.
- W4246418337 cites W2315494976 @default.
- W4246418337 doi "https://doi.org/10.1128/mcb.11.10.4918-4926.1991" @default.
- W4246418337 hasPublicationYear "1991" @default.
- W4246418337 type Work @default.
- W4246418337 citedByCount "0" @default.
- W4246418337 crossrefType "journal-article" @default.
- W4246418337 hasAuthorship W4246418337A5076662333 @default.
- W4246418337 hasAuthorship W4246418337A5083029357 @default.
- W4246418337 hasConcept C104317684 @default.
- W4246418337 hasConcept C156860981 @default.
- W4246418337 hasConcept C158448853 @default.
- W4246418337 hasConcept C19408993 @default.
- W4246418337 hasConcept C199216141 @default.
- W4246418337 hasConcept C3017666073 @default.
- W4246418337 hasConcept C413212 @default.
- W4246418337 hasConcept C54355233 @default.
- W4246418337 hasConcept C552990157 @default.
- W4246418337 hasConcept C55493867 @default.
- W4246418337 hasConcept C86339819 @default.
- W4246418337 hasConcept C86803240 @default.
- W4246418337 hasConcept C95444343 @default.
- W4246418337 hasConceptScore W4246418337C104317684 @default.
- W4246418337 hasConceptScore W4246418337C156860981 @default.
- W4246418337 hasConceptScore W4246418337C158448853 @default.
- W4246418337 hasConceptScore W4246418337C19408993 @default.
- W4246418337 hasConceptScore W4246418337C199216141 @default.
- W4246418337 hasConceptScore W4246418337C3017666073 @default.
- W4246418337 hasConceptScore W4246418337C413212 @default.
- W4246418337 hasConceptScore W4246418337C54355233 @default.
- W4246418337 hasConceptScore W4246418337C552990157 @default.
- W4246418337 hasConceptScore W4246418337C55493867 @default.
- W4246418337 hasConceptScore W4246418337C86339819 @default.
- W4246418337 hasConceptScore W4246418337C86803240 @default.
- W4246418337 hasConceptScore W4246418337C95444343 @default.
- W4246418337 hasIssue "10" @default.
- W4246418337 hasLocation W42464183371 @default.
- W4246418337 hasOpenAccess W4246418337 @default.
- W4246418337 hasPrimaryLocation W42464183371 @default.
- W4246418337 hasRelatedWork W2065684737 @default.
- W4246418337 hasRelatedWork W2089621556 @default.
- W4246418337 hasRelatedWork W2104142426 @default.
- W4246418337 hasRelatedWork W2104454968 @default.
- W4246418337 hasRelatedWork W2107014487 @default.
- W4246418337 hasRelatedWork W2111002047 @default.
- W4246418337 hasRelatedWork W2144753587 @default.
- W4246418337 hasRelatedWork W2153196983 @default.
- W4246418337 hasRelatedWork W233770993 @default.
- W4246418337 hasRelatedWork W4280525577 @default.
- W4246418337 hasVolume "11" @default.
- W4246418337 isParatext "false" @default.
- W4246418337 isRetracted "false" @default.
- W4246418337 workType "article" @default.