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- W4246420165 abstract "Abstract Background Titanium dioxide nanoparticles (TiO 2 NPs) are important nanomaterials with wide commercial applications. While the small size of TiO 2 NPs is useful in various applications, their biosafety should be evaluated further. In this study, we investigated the cytotoxicity of TiO 2 NPs in the presence and absence of UVA irradiation in human keratinocyte HaCaT cells. Results TiO 2 NPs did not significantly affect cell viability in the absence of UVA irradiation. However, UVA-irradiated TiO 2 NPs induced caspase-dependent apoptosis. Exposure of HaCaT cells to TiO 2 NPs and UVA resulted in reactive oxygen species (ROS) generation, and lysosomal membrane permeabilization (LMP); both effects were absent without UVA irradiation. An analysis of the relationship between LMP and ROS, using CA-074 as a cathepsin inhibitor or NAC as an antioxidant, showed that LMP stimulates ROS generation under these conditions. Conclusion These results imply that LMP-dependent oxidative stress plays a critical role in the UVA phototoxicity of TiO 2 NPs in HaCaT cells." @default.
- W4246420165 created "2022-05-12" @default.
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- W4246420165 date "2021-03-18" @default.
- W4246420165 modified "2023-09-27" @default.
- W4246420165 title "Titanium dioxide induces apoptosis under UVA irradiation via the generation of lysosomal membrane permeabilization-dependent reactive oxygen species in HaCaT cells" @default.
- W4246420165 doi "https://doi.org/10.21203/rs.3.rs-315515/v1" @default.
- W4246420165 hasPublicationYear "2021" @default.
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