Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246426318> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4246426318 endingPage "39" @default.
- W4246426318 startingPage "33" @default.
- W4246426318 abstract "Transbuccal administration of drugs provides an easy route of administration. To test the safety and efficacy of a novel testosterone (T) product, we performed a randomized, double blind, placebo-controlled study in a parallel design. Men with serum T levels below 250 ng/dL were administered either an active buccal tablet containing 10 mg T (n = 7) or a buccal placebo tablet (n = 6) containing 3 mg pseudoephedrine HCl for taste matching. Men were studied while taking a standard T enanthate dose, after 6 weeks of a wash-out period, and after 8 weeks of therapy. The men were matched for age (mean ± sd, 41 ± 16 vs. 47 ± 16) and type of hypogonadism (three primary testicular failures in each group, with the remainder having a central etiology). Acute pharmacokinetic testing showed peak serum hormone levels at 30 min, with a mean serum T concentration of 2688 ± 147 ng/dL (range, 1820–3770 ng/dL). Levels returned to baseline in 4–6 h, resulting in a total T area under the curve level of 3865 ng/hn·dL, less than that using other available forms of T administration. Similar pharmacokinetics were observed for the hormone’s metabolites, bioavailable T, free T, and estradiol. After 8 weeks of treatment, the results of nocturnal penile tumescence studies evaluating rigidity and circumference were significantly different from those in the placebo group (P < 0.05) and comparable to those during T enanthate therapy. In conclusion, transbuccal T therapy was sufficient to maintain normal sexual function while minimizing the total time of exposure to elevated circulating serum T levels." @default.
- W4246426318 created "2022-05-12" @default.
- W4246426318 creator A5009516582 @default.
- W4246426318 creator A5018847170 @default.
- W4246426318 creator A5041701447 @default.
- W4246426318 creator A5053583441 @default.
- W4246426318 date "1998-01-01" @default.
- W4246426318 modified "2023-09-28" @default.
- W4246426318 title "Pharmacokinetic Characteristics, Efficacy, and Safety of Buccal Testosterone in Hypogonadal Males: A Pilot Study1" @default.
- W4246426318 cites W1010041877 @default.
- W4246426318 cites W1986300867 @default.
- W4246426318 cites W2000378909 @default.
- W4246426318 cites W2013360023 @default.
- W4246426318 cites W2015029684 @default.
- W4246426318 cites W2033595545 @default.
- W4246426318 cites W2041388451 @default.
- W4246426318 cites W2042927990 @default.
- W4246426318 cites W2047903626 @default.
- W4246426318 cites W2086093979 @default.
- W4246426318 cites W2097913047 @default.
- W4246426318 cites W2131353173 @default.
- W4246426318 cites W2316831615 @default.
- W4246426318 cites W301898889 @default.
- W4246426318 cites W4301763483 @default.
- W4246426318 cites W71919669 @default.
- W4246426318 doi "https://doi.org/10.1210/jcem.83.1.4505" @default.
- W4246426318 hasPublicationYear "1998" @default.
- W4246426318 type Work @default.
- W4246426318 citedByCount "1" @default.
- W4246426318 countsByYear W42464263182022 @default.
- W4246426318 crossrefType "journal-article" @default.
- W4246426318 hasAuthorship W4246426318A5009516582 @default.
- W4246426318 hasAuthorship W4246426318A5018847170 @default.
- W4246426318 hasAuthorship W4246426318A5041701447 @default.
- W4246426318 hasAuthorship W4246426318A5053583441 @default.
- W4246426318 hasBestOaLocation W42464263181 @default.
- W4246426318 hasConcept C112705442 @default.
- W4246426318 hasConcept C126322002 @default.
- W4246426318 hasConcept C126894567 @default.
- W4246426318 hasConcept C134018914 @default.
- W4246426318 hasConcept C142724271 @default.
- W4246426318 hasConcept C195735259 @default.
- W4246426318 hasConcept C204787440 @default.
- W4246426318 hasConcept C27081682 @default.
- W4246426318 hasConcept C2779279991 @default.
- W4246426318 hasConcept C2779350572 @default.
- W4246426318 hasConcept C71924100 @default.
- W4246426318 hasConcept C98274493 @default.
- W4246426318 hasConceptScore W4246426318C112705442 @default.
- W4246426318 hasConceptScore W4246426318C126322002 @default.
- W4246426318 hasConceptScore W4246426318C126894567 @default.
- W4246426318 hasConceptScore W4246426318C134018914 @default.
- W4246426318 hasConceptScore W4246426318C142724271 @default.
- W4246426318 hasConceptScore W4246426318C195735259 @default.
- W4246426318 hasConceptScore W4246426318C204787440 @default.
- W4246426318 hasConceptScore W4246426318C27081682 @default.
- W4246426318 hasConceptScore W4246426318C2779279991 @default.
- W4246426318 hasConceptScore W4246426318C2779350572 @default.
- W4246426318 hasConceptScore W4246426318C71924100 @default.
- W4246426318 hasConceptScore W4246426318C98274493 @default.
- W4246426318 hasIssue "1" @default.
- W4246426318 hasLocation W42464263181 @default.
- W4246426318 hasOpenAccess W4246426318 @default.
- W4246426318 hasPrimaryLocation W42464263181 @default.
- W4246426318 hasRelatedWork W1984559885 @default.
- W4246426318 hasRelatedWork W1988486434 @default.
- W4246426318 hasRelatedWork W1998113603 @default.
- W4246426318 hasRelatedWork W1999611386 @default.
- W4246426318 hasRelatedWork W1999831221 @default.
- W4246426318 hasRelatedWork W2026882188 @default.
- W4246426318 hasRelatedWork W2027237635 @default.
- W4246426318 hasRelatedWork W2047880909 @default.
- W4246426318 hasRelatedWork W2049287171 @default.
- W4246426318 hasRelatedWork W2100202028 @default.
- W4246426318 hasVolume "83" @default.
- W4246426318 isParatext "false" @default.
- W4246426318 isRetracted "false" @default.
- W4246426318 workType "article" @default.