Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246438863> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4246438863 endingPage "405" @default.
- W4246438863 startingPage "405" @default.
- W4246438863 abstract "A new, mechanistically based approach is presented for the quantitative determination of the uncoupling and inhibitory activity of compounds interfering with energy transduction. Time-resolved spectroscopy of single-turnover events in the photosystem of the photosynthetic bacterium Rhodobacter sphaeroides can quantitatively distinguish uncoupling from inhibition. The decay kinetics of the membrane potential after a single turnover flash are used as a measure of uncoupling activity, and the redox kinetics of several components of the electron transfer chain are used as indicators of specific inhibition at various potential inhibitory sites. Results are presented for 21 nitrated and chlorinated phenols, some reference uncouplers, and some anisoles. Inhibition was exclusively detected at one specific quinone binding site, the quinone reductase site Qi. For most phenols, uncoupling was observed at lower concentrations than inhibition with the exception of alkylated 2,6-dinitrophenols and 2,4,6-trichlorophenol, where both effects occurred in the same concentration range. No direct correlation was observed between the uncoupling and inhibitory activity of a given compound. The data obtained with this new method correlate well with data from various bioassays on energy-transducing systems, indicating that this method may also be well suited as a screening tool for compounds suspected to interfere with energy transduction." @default.
- W4246438863 created "2022-05-12" @default.
- W4246438863 creator A5019740923 @default.
- W4246438863 creator A5064613020 @default.
- W4246438863 creator A5088019295 @default.
- W4246438863 creator A5089664368 @default.
- W4246438863 date "1997-01-01" @default.
- W4246438863 modified "2023-10-10" @default.
- W4246438863 title "A NEW METHOD FOR SIMULTANEOUS QUANTIFICATION OF UNCOUPLING AND INHIBITORY ACTIVITY OF ORGANIC POLLUTANTS IN ENERGY-TRANSDUCING MEMBRANES" @default.
- W4246438863 doi "https://doi.org/10.1897/1551-5028(1997)016<0405:anmfsq>2.3.co;2" @default.
- W4246438863 hasPublicationYear "1997" @default.
- W4246438863 type Work @default.
- W4246438863 citedByCount "1" @default.
- W4246438863 countsByYear W42464388632020 @default.
- W4246438863 crossrefType "journal-article" @default.
- W4246438863 hasAuthorship W4246438863A5019740923 @default.
- W4246438863 hasAuthorship W4246438863A5064613020 @default.
- W4246438863 hasAuthorship W4246438863A5088019295 @default.
- W4246438863 hasAuthorship W4246438863A5089664368 @default.
- W4246438863 hasConcept C121332964 @default.
- W4246438863 hasConcept C12554922 @default.
- W4246438863 hasConcept C148898269 @default.
- W4246438863 hasConcept C169760540 @default.
- W4246438863 hasConcept C17077164 @default.
- W4246438863 hasConcept C181911157 @default.
- W4246438863 hasConcept C183688256 @default.
- W4246438863 hasConcept C185592680 @default.
- W4246438863 hasConcept C206865886 @default.
- W4246438863 hasConcept C24840226 @default.
- W4246438863 hasConcept C2777897970 @default.
- W4246438863 hasConcept C2780643102 @default.
- W4246438863 hasConcept C2910689142 @default.
- W4246438863 hasConcept C41625074 @default.
- W4246438863 hasConcept C55493867 @default.
- W4246438863 hasConcept C57600042 @default.
- W4246438863 hasConcept C62520636 @default.
- W4246438863 hasConcept C80298142 @default.
- W4246438863 hasConcept C86803240 @default.
- W4246438863 hasConceptScore W4246438863C121332964 @default.
- W4246438863 hasConceptScore W4246438863C12554922 @default.
- W4246438863 hasConceptScore W4246438863C148898269 @default.
- W4246438863 hasConceptScore W4246438863C169760540 @default.
- W4246438863 hasConceptScore W4246438863C17077164 @default.
- W4246438863 hasConceptScore W4246438863C181911157 @default.
- W4246438863 hasConceptScore W4246438863C183688256 @default.
- W4246438863 hasConceptScore W4246438863C185592680 @default.
- W4246438863 hasConceptScore W4246438863C206865886 @default.
- W4246438863 hasConceptScore W4246438863C24840226 @default.
- W4246438863 hasConceptScore W4246438863C2777897970 @default.
- W4246438863 hasConceptScore W4246438863C2780643102 @default.
- W4246438863 hasConceptScore W4246438863C2910689142 @default.
- W4246438863 hasConceptScore W4246438863C41625074 @default.
- W4246438863 hasConceptScore W4246438863C55493867 @default.
- W4246438863 hasConceptScore W4246438863C57600042 @default.
- W4246438863 hasConceptScore W4246438863C62520636 @default.
- W4246438863 hasConceptScore W4246438863C80298142 @default.
- W4246438863 hasConceptScore W4246438863C86803240 @default.
- W4246438863 hasIssue "3" @default.
- W4246438863 hasLocation W42464388631 @default.
- W4246438863 hasOpenAccess W4246438863 @default.
- W4246438863 hasPrimaryLocation W42464388631 @default.
- W4246438863 hasRelatedWork W1541489694 @default.
- W4246438863 hasRelatedWork W2051954220 @default.
- W4246438863 hasRelatedWork W2097074792 @default.
- W4246438863 hasRelatedWork W2116448908 @default.
- W4246438863 hasRelatedWork W2327829412 @default.
- W4246438863 hasRelatedWork W2412138612 @default.
- W4246438863 hasRelatedWork W2606117830 @default.
- W4246438863 hasRelatedWork W2728603622 @default.
- W4246438863 hasRelatedWork W294080940 @default.
- W4246438863 hasRelatedWork W4313352940 @default.
- W4246438863 hasVolume "16" @default.
- W4246438863 isParatext "false" @default.
- W4246438863 isRetracted "false" @default.
- W4246438863 workType "article" @default.