Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246457174> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4246457174 endingPage "37" @default.
- W4246457174 startingPage "33" @default.
- W4246457174 abstract "Addition of primary amines to the aqueous solution of thiamine, in the presence of sulfurous acid, results in almost quantitative substitution of its thiazole portion with primary amines. Use of aniline and p-aminobenzoic acid as the primary amine, respectively yields N-[2-methyl-4-aminopyrimidyl-(5)]-methylaniline (I) and -methyl-p-aminobenzoic acid (IV), which are respectively identical with the substances obtained by the condensation of aniline or p-aminobenzoic acid with 2-methyl-4-amino-5-bromo-methylpyrimidine hydrobromide (III). This reaction also occurs with the use of indole, forming N-[2-methyl-4-aminopyrimidyl-(5)]-methylindole (V) from thiamine. (V) is identical with the substance obtained by the condensation of (III) and indole. The thiamine derivative substituted with pyridine or quinoline in its thiazole portion, i.e. N-[2-methyl-4-aminopyrimidyl-(5)]-methyl-pyridinium or -quinolinium compounds also form (I) in good yields in the presence of sulfurous acid and aniline. These results are quite similar to the state of decomposition of thiamine by the thiamine destructive enzyme and are of interest as a model experiment for enzymatic activity." @default.
- W4246457174 created "2022-05-12" @default.
- W4246457174 creator A5016071726 @default.
- W4246457174 creator A5030797512 @default.
- W4246457174 date "1952-01-01" @default.
- W4246457174 modified "2023-10-10" @default.
- W4246457174 title "Studies on Vitamin B<sub>1</sub> and Related Compounds. XXVI" @default.
- W4246457174 doi "https://doi.org/10.1248/yakushi1947.72.1_33" @default.
- W4246457174 hasPublicationYear "1952" @default.
- W4246457174 type Work @default.
- W4246457174 citedByCount "5" @default.
- W4246457174 countsByYear W42464571742016 @default.
- W4246457174 crossrefType "journal-article" @default.
- W4246457174 hasAuthorship W4246457174A5016071726 @default.
- W4246457174 hasAuthorship W4246457174A5030797512 @default.
- W4246457174 hasBestOaLocation W42464571741 @default.
- W4246457174 hasConcept C131779359 @default.
- W4246457174 hasConcept C155647269 @default.
- W4246457174 hasConcept C178790620 @default.
- W4246457174 hasConcept C185592680 @default.
- W4246457174 hasConcept C2776203871 @default.
- W4246457174 hasConcept C2776309666 @default.
- W4246457174 hasConcept C2776514930 @default.
- W4246457174 hasConcept C2778464347 @default.
- W4246457174 hasConcept C2779176119 @default.
- W4246457174 hasConcept C2779244968 @default.
- W4246457174 hasConcept C2779485729 @default.
- W4246457174 hasConcept C2909243696 @default.
- W4246457174 hasConcept C55493867 @default.
- W4246457174 hasConceptScore W4246457174C131779359 @default.
- W4246457174 hasConceptScore W4246457174C155647269 @default.
- W4246457174 hasConceptScore W4246457174C178790620 @default.
- W4246457174 hasConceptScore W4246457174C185592680 @default.
- W4246457174 hasConceptScore W4246457174C2776203871 @default.
- W4246457174 hasConceptScore W4246457174C2776309666 @default.
- W4246457174 hasConceptScore W4246457174C2776514930 @default.
- W4246457174 hasConceptScore W4246457174C2778464347 @default.
- W4246457174 hasConceptScore W4246457174C2779176119 @default.
- W4246457174 hasConceptScore W4246457174C2779244968 @default.
- W4246457174 hasConceptScore W4246457174C2779485729 @default.
- W4246457174 hasConceptScore W4246457174C2909243696 @default.
- W4246457174 hasConceptScore W4246457174C55493867 @default.
- W4246457174 hasIssue "1" @default.
- W4246457174 hasLocation W42464571741 @default.
- W4246457174 hasOpenAccess W4246457174 @default.
- W4246457174 hasPrimaryLocation W42464571741 @default.
- W4246457174 hasRelatedWork W1545662458 @default.
- W4246457174 hasRelatedWork W1714699844 @default.
- W4246457174 hasRelatedWork W1994325596 @default.
- W4246457174 hasRelatedWork W2087192256 @default.
- W4246457174 hasRelatedWork W2210858015 @default.
- W4246457174 hasRelatedWork W2238177662 @default.
- W4246457174 hasRelatedWork W2349301072 @default.
- W4246457174 hasRelatedWork W2604155874 @default.
- W4246457174 hasRelatedWork W2747942092 @default.
- W4246457174 hasRelatedWork W290672717 @default.
- W4246457174 hasVolume "72" @default.
- W4246457174 isParatext "false" @default.
- W4246457174 isRetracted "false" @default.
- W4246457174 workType "article" @default.