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- W4246458237 abstract "Cushing’s disease (CD), which is caused by an ACTH-secreting pituitary corticotroph adenoma, is the commonest cause of Cushing’s syndrome in children over 5 years of age. However, it remains rare in the pediatric age range and may present a difficult diagnostic and therapeutic challenge. Key presenting features include weight gain associated with growth failure. Parents and general practitioners frequently fail to appreciate the nature of the pathology, significantly delaying diagnosis. Most pediatric endocrinologists have limited experience managing children or adolescents with CD and thus benefit from close consultation with adult colleagues. We describe a diagnostic protocol for investigation that broadly follows the model for adult patients. Treatment strategies for CD are examined and critically appraised. The management of pediatric CD patients after cure is also discussed, as it presents unique challenges for optimizing growth, bone health, reproduction, and body composition from childhood into and during adult life." @default.
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- W4246458237 date "2011-01-01" @default.
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- W4246458237 title "Diagnosis and Treatment of Pediatric Cushing’s Disease" @default.
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