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- W4246468204 abstract "Encouraging data as to the therapeutic value of para-aminobenzoic acid in the treatment of experimental tsutsugamushi disease (scrub typhus or dangerous bug disease) are reported by Snyder and his associates<sup>1</sup>of the Cairo unit of the United States of America Typhus Commission. Previously Zarafonetis,<sup>2</sup>a member of the typhus commission, had found that 2 small mouselike rodents (Gerbillus gerbillus and Gerbillus pyramidun) common in Asia, Africa and southern Russia are readily susceptible to Rickettsia orientalis. When inoculated intraperitoneally, subcutaneously or intravenously 100 per cent of the gerbilles succumbed to the disease. Smears of the peritoneal and pleural exudates showed numerous pleomorphic rickettsias within the cytoplasm of the pus cells. Following reported beneficial effects of para-aminobenzoic acid in the treatment of classic louse borne typhus in human beings,<sup>3</sup>the commission tested its possible therapeutic effect on gerbilles after lethal inoculation with several different strains of Rickettsia orientalis. The" @default.
- W4246468204 created "2022-05-12" @default.
- W4246468204 date "1946-02-02" @default.
- W4246468204 modified "2023-10-17" @default.
- W4246468204 title "PARA-AMINOBENZOIC ACID THERAPY FOR TSUTSUGAMUSHI FEVER" @default.
- W4246468204 doi "https://doi.org/10.1001/jama.1946.02870050030009" @default.
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