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• W4246471661 abstract "The expression ofβ1,β2,β3,γ2 and δ subunit messenger RNAs of the GABAA receptor was followed by in situ hybridization histochemistry using radiolabeled oligodeoxynucleotide probes in sections of embryonic (E12–21) and early postnatal (P1–5) rat. β2,β3 andγ2 subunit messenger RNAs were first detectable at E15 in the spinal cord (ventral > dorsal) and lower central nervous system regions (e.g. pons, medulla and thalamus).β3 subunit messenger RNA was abundantly expressed in olfactory bulb neurons at E15. At E17, the expression pattern of these subunit messenger RNAs continued in the lower central nervous system. In the upper central nervous system,β2,β3 andγ2 subunit messenger RNAs were first detectable in the outer layer of the hippocampal and entire cortical neuroepithelium. The expression for bothβ3 andγ2 subunit messenger RNAs increased significantly over that observed at E15, whereasβ2 subunit messenger RNA increased to a lesser extent and was more discretely expressed in inferior colliculus, cerebellar neuroepithelium and spinal cord (ventral = dorsal). By E19, messenger RNAs forβ2,β3 andγ2 subunits displayed a widespread and abundant co-existent distribution throughout the central nervous system. Exceptions to this co-expression were the absence ofβ2 messenger RNA in the dentate gyrus andβ3 messenger RNA in entorhinal cortex, areas in which they are present in adult. There was also a differential distribution of subunit messenger RNAs in developing olfactory bulb at E19–20: the glomerular cells preferentially expressedβ3 andγ2 subunit messenger RNAs; the mitral cells preferentially expressedβ2 subunit messenger RNA; inner granule cells expressed moderate levels ofβ2,β3 andγ2 subunit messenger RNAs. Expression ofβ2,β3 andγ2 messenger RNAs was also anatomically co-existent at P5. In addition, significant expression ofβ1 and δ subunit messenger RNAs was apparent in hippocampus and entorhinal cortex. The identity of theγ2 expressed between E15 and E21 was shown to be mostly the short isoform ofγ2 subunit messenger RNA. Expression of both forms was evident beginning around P3–5.These results indicate that during the late embryonic and early postnatal period of development,β2,β3 andγ2 subunit messenger RNAs are abundantly expressed and co-localized to most central nervous system regions. The anatomical and cellular distribution of these GABAA subunit messenger RNAs, as well as those coding for specific α subunits [Poulter M.O. et al. (1992) J. Neurosci.12, 2888–2890] indicates that the expression of GABAA receptor subunit messenger RNA is a complex and dynamic process, giving rise to a pattern that has constant and variable features which often differ from distributions seen in the adult CNS. This ontogenetic profile is consistent with the evidence that GABAA receptors play a role in synaptogenesis and/or cellular differentiation." @default.
• W4246471661 created "2022-05-12" @default.
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• W4246471661 date "1928-04-01" @default.
• W4246471661 modified "2023-09-30" @default.
• W4246471661 title "Committee on science and the arts" @default.
• W4246471661 doi "https://doi.org/10.1016/s0016-0032(28)90817-0" @default.
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