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- W4246475129 abstract "The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing all other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it progresses from the fertilized egg, through cleavage stage/morula blastomeres, blastocyst, inner cell mass, epiblast, germ cells, and gametes. The factors that regulate, and are regulated by, Oct-4 are reviewed with respect to the phenomena of cell potency and germ/soma segregation and differentiation. BioEssays 20:722–732, 1998. © 1998 John Wiley & Sons, Inc." @default.
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- W4246475129 date "1998-09-01" @default.
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- W4246475129 title "In line with our ancestors: Oct4 and the mammalian germ" @default.
- W4246475129 doi "https://doi.org/10.1002/(sici)1521-1878(199809)20:9<722::aid-bies5>3.3.co;2-o" @default.
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