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- W4246517961 abstract "Abstract The reaction to synthesize 1,2,3,4‐tetrahydroisoquinoline by cyclo‐condensation of substituted benzylaminoacetals in the presence of hydrochloric acid, is generally referred to as the Bobbitt reaction. The boron trifluoride as a cyclizing reagent has not given suitable results for the synthesis of oxygenated isoquinolines. The Bobbitt reaction has overcome the potential problems via the addition of aliphatic Grignard reagents to the Schiff bases, followed by the cyclization and its modification. Besides this, various methods for the synthesis of N‐substituted 1,2,3,4‐isoquinoline and 4‐substitued 1,2,3,4‐isoquinoline (4‐OH‐1,2,3,4‐isoquinoline) have been explored in the present study." @default.
- W4246517961 created "2022-05-12" @default.
- W4246517961 date "2010-09-15" @default.
- W4246517961 modified "2023-10-16" @default.
- W4246517961 title "Bobbitt Reaction" @default.
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- W4246517961 doi "https://doi.org/10.1002/9780470638859.conrr095" @default.
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