FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246536807> ?p ?o ?g. }

• W4246536807 abstract "<b>Objective</b>: Evaluate the associations between long-term change and variability in glycemia with risk of HF among patients with T2DM. <p><b>Research Design and Methods: </b>Among participants with T2DM enrolled in the ACCORD trial, variability in HbA1c was assessed from stabilization of HbA1c following enrollment (8 months) to 3 years of follow-up as follows: average successive variability (ASV=average absolute difference between successive values), coefficient of variation (CV=standard deviation/mean), and standard deviation. Participants with HF at baseline or within 3 years of enrollment were excluded. Adjusted Cox models were used to evaluate the association of % change (from baseline to 3 years of follow-up) and variability in HbA1c over the first 3 years of enrollment and subsequent risk of HF.</p> <p><b>Results</b>: The study included 8,576 patients. Over a median follow-up of 6.4 years from the end of variability measurements at year 3, 388 patients had an incident HF hospitalization. Substantial changes in HbA1c were significantly associated with higher risk of HF [HR (95% CI) for ≥10% decrease = 1.32 (1.08-1.75), ≥10% increase = 1.55 (1.19-2.04), ref: <10% change in HbA1c]. Higher long-term variability in HbA1c was significantly associated with higher risk of HF [HR (95% CI) per 1 SD of ASV = 1.34 (1.17-1.54)] independent of baseline risk factors and interval changes in cardiometabolic parameters. Consistent patterns of association were observed using alternative measures of glycemic variability.</p> <p><b>Conclusions:</b> Substantial long-term changes and variability in HbA1c were independently associated with risk of HF among patients with T2DM.</p>" @default.
• W4246536807 created "2022-05-12" @default.
• W4246536807 creator A5007166261 @default.
• W4246536807 creator A5022314919 @default.
• W4246536807 creator A5024931198 @default.
• W4246536807 creator A5027221074 @default.
• W4246536807 creator A5033269110 @default.
• W4246536807 creator A5037939005 @default.
• W4246536807 creator A5061881316 @default.
• W4246536807 creator A5070928171 @default.
• W4246536807 creator A5071945904 @default.
• W4246536807 date "2020-06-17" @default.
• W4246536807 modified "2023-10-18" @default.
• W4246536807 title "Association of Long-Term Change and Variability in Glycemia with Risk of Incident Heart Failure among Patients with Type 2 Diabetes Mellitus – A Secondary Analysis of the ACCORD Trial" @default.
• W4246536807 doi "https://doi.org/10.2337/figshare.12273155.v2" @default.
• W4246536807 hasPublicationYear "2020" @default.
• W4246536807 type Work @default.
• W4246536807 citedByCount "0" @default.
• W4246536807 crossrefType "posted-content" @default.
• W4246536807 hasAuthorship W4246536807A5007166261 @default.
• W4246536807 hasAuthorship W4246536807A5022314919 @default.
• W4246536807 hasAuthorship W4246536807A5024931198 @default.
• W4246536807 hasAuthorship W4246536807A5027221074 @default.
• W4246536807 hasAuthorship W4246536807A5033269110 @default.
• W4246536807 hasAuthorship W4246536807A5037939005 @default.
• W4246536807 hasAuthorship W4246536807A5061881316 @default.
• W4246536807 hasAuthorship W4246536807A5070928171 @default.
• W4246536807 hasAuthorship W4246536807A5071945904 @default.
• W4246536807 hasBestOaLocation W42465368071 @default.
• W4246536807 hasConcept C105795698 @default.
• W4246536807 hasConcept C126322002 @default.
• W4246536807 hasConcept C134018914 @default.
• W4246536807 hasConcept C2778198053 @default.
• W4246536807 hasConcept C33923547 @default.
• W4246536807 hasConcept C44249647 @default.
• W4246536807 hasConcept C555293320 @default.
• W4246536807 hasConcept C71924100 @default.
• W4246536807 hasConcept C89838059 @default.
• W4246536807 hasConceptScore W4246536807C105795698 @default.
• W4246536807 hasConceptScore W4246536807C126322002 @default.
• W4246536807 hasConceptScore W4246536807C134018914 @default.
• W4246536807 hasConceptScore W4246536807C2778198053 @default.
• W4246536807 hasConceptScore W4246536807C33923547 @default.
• W4246536807 hasConceptScore W4246536807C44249647 @default.
• W4246536807 hasConceptScore W4246536807C555293320 @default.
• W4246536807 hasConceptScore W4246536807C71924100 @default.
• W4246536807 hasConceptScore W4246536807C89838059 @default.
• W4246536807 hasLocation W42465368071 @default.
• W4246536807 hasLocation W42465368072 @default.
• W4246536807 hasOpenAccess W4246536807 @default.
• W4246536807 hasPrimaryLocation W42465368071 @default.
• W4246536807 hasRelatedWork W13794429 @default.
• W4246536807 hasRelatedWork W14698401 @default.
• W4246536807 hasRelatedWork W15195943 @default.
• W4246536807 hasRelatedWork W21391546 @default.
• W4246536807 hasRelatedWork W288983 @default.
• W4246536807 hasRelatedWork W463560 @default.
• W4246536807 hasRelatedWork W6071 @default.
• W4246536807 hasRelatedWork W6291807 @default.
• W4246536807 hasRelatedWork W12338757 @default.
• W4246536807 hasRelatedWork W3755982 @default.
• W4246536807 isParatext "false" @default.
• W4246536807 isRetracted "false" @default.
• W4246536807 workType "article" @default.