FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246585146> ?p ?o ?g. }

• W4246585146 endingPage "553" @default.
• W4246585146 startingPage "543" @default.
• W4246585146 abstract "Previous analyses defined a proliferating cell nuclear antigen (PCNA) E1A-responsive element (PERE) in the PCNA promoter that is essential for transactivation by the 243-residue product of the adenovirus type 2 E1A 12S mRNA (E1A 243R). In this report, we show that the PERE activates a heterologous basal promoter and confers susceptibility to transactivation by E1A 243R, indicating that the PERE is both necessary and sufficient for the response of the PCNA promoter to this oncoprotein. Insertion of linker sequences between the PERE and the site of transcription initiation in the PCNA promoter severely impairs the promoter's response to E1A 243R transactivation. GAL4 sites can replace the function of the PERE in the E1A 243R response of the PCNA basal promoter if transcriptional activators of suitable strength are supplied as GAL4 fusion proteins. Weak transcriptional activators render the PCNA basal promoter subject to transactivation by E1A 243R but do not endow the adenovirus E1B basal promoter with a similar response. Strong transcriptional activators do not support transactivation by E1A 243R, however; instead, E1A reduces the ability of the strong activators to activate both the PCNA and E1B basal promoters. Although other mechanistic differences might determine the response, the data imply a relationship between the activation strength of promoter-proximal effectors and the response of the PCNA basal promoter to E1A 243R. These experiments indicate that the PERE can function autonomously in mediating transactivation by E1A 243R and that the PCNA basal promoter is configured in a manner that permits modulation by E1A 243R of transcriptional activation by promoter-proximal effectors." @default.
• W4246585146 created "2022-05-12" @default.
• W4246585146 creator A5018004018 @default.
• W4246585146 creator A5063151736 @default.
• W4246585146 creator A5085282969 @default.
• W4246585146 date "1994-01-01" @default.
• W4246585146 modified "2023-10-17" @default.
• W4246585146 title "Modulation of transcriptional activation of the proliferating cell nuclear antigen promoter by the adenovirus E1A 243-residue oncoprotein depends on proximal activators" @default.
• W4246585146 cites W1221384716 @default.
• W4246585146 cites W126863029 @default.
• W4246585146 cites W1503849321 @default.
• W4246585146 cites W1509615239 @default.
• W4246585146 cites W1523094058 @default.
• W4246585146 cites W1525913425 @default.
• W4246585146 cites W1569934864 @default.
• W4246585146 cites W1571644961 @default.
• W4246585146 cites W1581478432 @default.
• W4246585146 cites W1583104418 @default.
• W4246585146 cites W1692197226 @default.
• W4246585146 cites W1839493148 @default.
• W4246585146 cites W1843163606 @default.
• W4246585146 cites W1884174895 @default.
• W4246585146 cites W1886708724 @default.
• W4246585146 cites W1958059146 @default.
• W4246585146 cites W1960870195 @default.
• W4246585146 cites W1966156883 @default.
• W4246585146 cites W1969881374 @default.
• W4246585146 cites W1975166077 @default.
• W4246585146 cites W1975712471 @default.
• W4246585146 cites W1979647722 @default.
• W4246585146 cites W1980483123 @default.
• W4246585146 cites W1983090927 @default.
• W4246585146 cites W1986943051 @default.
• W4246585146 cites W1989969910 @default.
• W4246585146 cites W1995012997 @default.
• W4246585146 cites W1999156595 @default.
• W4246585146 cites W2000082154 @default.
• W4246585146 cites W2007080316 @default.
• W4246585146 cites W2007754578 @default.
• W4246585146 cites W2013345205 @default.
• W4246585146 cites W2013607556 @default.
• W4246585146 cites W2013980278 @default.
• W4246585146 cites W2015502095 @default.
• W4246585146 cites W2015617558 @default.
• W4246585146 cites W2016676541 @default.
• W4246585146 cites W2023375991 @default.
• W4246585146 cites W2023666553 @default.
• W4246585146 cites W2027216583 @default.
• W4246585146 cites W2029440030 @default.
• W4246585146 cites W2030156849 @default.
• W4246585146 cites W2031504305 @default.
• W4246585146 cites W2032055870 @default.
• W4246585146 cites W2032210572 @default.
• W4246585146 cites W2033777731 @default.
• W4246585146 cites W2035762638 @default.
• W4246585146 cites W2037653294 @default.
• W4246585146 cites W2037705033 @default.
• W4246585146 cites W2041079932 @default.
• W4246585146 cites W2041230251 @default.
• W4246585146 cites W2041807810 @default.
• W4246585146 cites W2045135216 @default.
• W4246585146 cites W2054435912 @default.
• W4246585146 cites W2057058623 @default.
• W4246585146 cites W2063798194 @default.
• W4246585146 cites W2065637469 @default.
• W4246585146 cites W2068577315 @default.
• W4246585146 cites W2074728647 @default.
• W4246585146 cites W2080053060 @default.
• W4246585146 cites W2083522684 @default.
• W4246585146 cites W2088577765 @default.
• W4246585146 cites W2088622701 @default.
• W4246585146 cites W2089241243 @default.
• W4246585146 cites W209276256 @default.
• W4246585146 cites W2093897768 @default.
• W4246585146 cites W2094807913 @default.
• W4246585146 cites W2101290459 @default.
• W4246585146 cites W2107624922 @default.
• W4246585146 cites W2109399660 @default.
• W4246585146 cites W2111393771 @default.
• W4246585146 cites W2130116014 @default.
• W4246585146 cites W2132781864 @default.
• W4246585146 cites W2133084943 @default.
• W4246585146 cites W2134926960 @default.
• W4246585146 cites W2139476145 @default.
• W4246585146 cites W2144206181 @default.
• W4246585146 cites W2145312783 @default.
• W4246585146 cites W2159361278 @default.
• W4246585146 cites W2163864783 @default.
• W4246585146 cites W2165409475 @default.
• W4246585146 cites W2220513149 @default.
• W4246585146 cites W4233873580 @default.
• W4246585146 doi "https://doi.org/10.1128/mcb.14.1.543-553.1994" @default.
• W4246585146 hasPublicationYear "1994" @default.
• W4246585146 type Work @default.
• W4246585146 citedByCount "6" @default.
• W4246585146 crossrefType "journal-article" @default.
• W4246585146 hasAuthorship W4246585146A5018004018 @default.
• W4246585146 hasAuthorship W4246585146A5063151736 @default.

• next