Matches in SemOpenAlex for { <https://semopenalex.org/work/W4246596135> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4246596135 abstract "BACKGROUND: We aimed to describe the epidemiology of candidemia among children in South Africa.METHODS: We conducted laboratory-based surveillance among neonates (≤28 days), infants (29 days to < 1 year), children (1-11 years) and adolescents (12-17 years) with Candida species cultured from blood during 2012-2017. Identification and antifungal susceptibility of viable isolates were performed at a reference laboratory. We used multivariable logistic regression to determine the association between Candida parapsilosis candidemia and 30-day mortality among neonates.RESULTS: Of 2996 cases, neonates accounted for 49% (n = 1478), infants for 27% (n = 806), children for 20% (n = 589) and adolescents for 4% (n = 123). The incidence risk at tertiary public sector hospitals was 5.3 cases per 1000 pediatric admissions (range 0.39-119.1). Among 2943 cases with single-species infections, C. parapsilosis (42%) and Candida albicans (36%) were most common. Candida auris was among the 5 common species with an overall prevalence of 3% (n = 47). Fluconazole resistance was more common among C. parapsilosis (55% [724/1324]) versus other species (19% [334/1737]) (P < 0.001). Of those with known treatment (n = 1666), 35% received amphotericin B deoxycholate alone, 32% fluconazole alone and 30% amphotericin B deoxycholate with fluconazole. The overall 30-day in-hospital mortality was 38% (n = 586) and was highest among neonates (43% [323/752]) and adolescents (43% [28/65]). Compared to infection with other species, C. parapsilosis infection was associated with a reduced mortality among neonates (adjusted odds ratio 0.41, 95% confidence interval: 0.22-0.75, P = 0.004).CONCLUSIONS: Candidemia in this setting mainly affected neonates and infants and was characterized by fluconazole-resistant C. parapsilosis with no increased risk of death.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. PMID: 33872278" @default.
- W4246596135 created "2022-05-12" @default.
- W4246596135 creator A5000854279 @default.
- W4246596135 date "2021-05-25" @default.
- W4246596135 modified "2023-09-27" @default.
- W4246596135 title "Faculty Opinions recommendation of Epidemiology of Culture-confirmed Candidemia Among Hospitalized Children in South Africa, 2012-2017." @default.
- W4246596135 doi "https://doi.org/10.3410/f.739967341.793585874" @default.
- W4246596135 hasPublicationYear "2021" @default.
- W4246596135 type Work @default.
- W4246596135 citedByCount "0" @default.
- W4246596135 crossrefType "dataset" @default.
- W4246596135 hasAuthorship W4246596135A5000854279 @default.
- W4246596135 hasConcept C107130276 @default.
- W4246596135 hasConcept C120665830 @default.
- W4246596135 hasConcept C121332964 @default.
- W4246596135 hasConcept C126322002 @default.
- W4246596135 hasConcept C151956035 @default.
- W4246596135 hasConcept C156957248 @default.
- W4246596135 hasConcept C16005928 @default.
- W4246596135 hasConcept C187212893 @default.
- W4246596135 hasConcept C2779443200 @default.
- W4246596135 hasConcept C2779548794 @default.
- W4246596135 hasConcept C2779629538 @default.
- W4246596135 hasConcept C2780651595 @default.
- W4246596135 hasConcept C44249647 @default.
- W4246596135 hasConcept C61511704 @default.
- W4246596135 hasConcept C71924100 @default.
- W4246596135 hasConceptScore W4246596135C107130276 @default.
- W4246596135 hasConceptScore W4246596135C120665830 @default.
- W4246596135 hasConceptScore W4246596135C121332964 @default.
- W4246596135 hasConceptScore W4246596135C126322002 @default.
- W4246596135 hasConceptScore W4246596135C151956035 @default.
- W4246596135 hasConceptScore W4246596135C156957248 @default.
- W4246596135 hasConceptScore W4246596135C16005928 @default.
- W4246596135 hasConceptScore W4246596135C187212893 @default.
- W4246596135 hasConceptScore W4246596135C2779443200 @default.
- W4246596135 hasConceptScore W4246596135C2779548794 @default.
- W4246596135 hasConceptScore W4246596135C2779629538 @default.
- W4246596135 hasConceptScore W4246596135C2780651595 @default.
- W4246596135 hasConceptScore W4246596135C44249647 @default.
- W4246596135 hasConceptScore W4246596135C61511704 @default.
- W4246596135 hasConceptScore W4246596135C71924100 @default.
- W4246596135 hasLocation W42465961351 @default.
- W4246596135 hasOpenAccess W4246596135 @default.
- W4246596135 hasPrimaryLocation W42465961351 @default.
- W4246596135 hasRelatedWork W2061398179 @default.
- W4246596135 hasRelatedWork W2089649651 @default.
- W4246596135 hasRelatedWork W2123942256 @default.
- W4246596135 hasRelatedWork W2288306407 @default.
- W4246596135 hasRelatedWork W2348392238 @default.
- W4246596135 hasRelatedWork W2379576354 @default.
- W4246596135 hasRelatedWork W2412657837 @default.
- W4246596135 hasRelatedWork W2954160877 @default.
- W4246596135 hasRelatedWork W3211349046 @default.
- W4246596135 hasRelatedWork W4292264128 @default.
- W4246596135 isParatext "false" @default.
- W4246596135 isRetracted "false" @default.
- W4246596135 workType "dataset" @default.